@article{3191454,
    title = "Cranial and ventricular size following shunting or endoscopic third
ventriculostomy (ETV) in infants with aqueductal stenosis: further
insights from the International Infant Hydrocephalus Study (IIHS)",
    author = "Coulter, Ian C. and Kulkarni, Abhaya V. and Sgouros, Spyros and and Constantini, Shlomi and Constantini, Shlomi and Sgouros, Spyros and and Kulkarni, Abhaya V. and Leitner, Yael and Kestle, John R. W. and and Cochrane, Douglas D. and Choux, Maurice and Gjerris, Fleming and Sherer, and Adina and Akalan, Nejat and Bilginer, Burcak and Navarro, Ramon and and Vujotic, Ljiljana and Haberl, Hannes and Thomale, Ulrich-Wilhelm and and Zuccaro, Graciela and Jaimovitch, Roberto and Frim, David and Loftis, and Lori and Swift, Dale M. and Robertson, Brian and Gargan, Lynn and and Bognar, Laszlo and Novak, Laszlo and Cseke, Georgina and Cama, Armando and and Ravegnani, Giuseppe Marcello and Preuss, Matthias and Schroeder, and Henry W. and Fritsch, Michael and Baldauf, Joerg and Mandera, Marek and and Luszawski, Jerzy and Skorupka, Patrycja and Mallucci, Conor and and Williams, Dawn and Zakrzewski, Krzysztof and Nowoslawska, Emilia and and Srivastava, Chhitij and Mahapatra, Ashok K. and Kumar, Raj and Sahu, and Rabi Narayan and Melikian, Armen G. and Korshunov, Anton and Galstyan, and Anna and Suri, Ashish and Gupta, Deepak and Grotenhuis, J. Andre and van and Lindert, Erik J. and da Costa Val, Jose Aloysio and Di Rocco, Concezio and and Tamburrini, Gianpiero and Zymberg, Samuel Tau and Cavalheiro, Sergio and and Jie, Ma and Feng, Jiang and Friedman, Orna and Rajmohamed, Naheeda and and Roszkowski, Marcin and Barszcz, Slawomir and Jallo, George and and Pincus, David W. and Richter, Bridget and Mehdorn, H. M. and Schultka, and Susan and de Ribaupierre, Sandrine and Thompson, Dominic and Gatscher, and Silvia and Wagner, Wolfgang and Koch, Dorothee and Cipri, Saverio and and Zaccone, Claudio and McDonald, Patrick and Int Infant Hydrocephalus and Study",
    journal = "Child's Nervous System",
    year = "2020",
    volume = "36",
    number = "7",
    pages = "1407-1414",
    publisher = "Springer-Verlag",
    issn = "0256-7040, 1433-0350",
    doi = "10.1007/s00381-020-04503-y",
    keywords = "International Infant Hydrocephalus Study; Infant hydrocephalus;
Endoscopic third ventriculostomy; Shunt",
    abstract = "Purpose The craniometrics of head circumference (HC) and ventricular
size are part of the clinical assessment of infants with hydrocephalus
and are often utilized in conjunction with other clinical and
radiological parameters to determine the success of treatment. We aimed
to assess the effect of endoscopic third ventriculostomy (ETV) and
shunting on craniometric measurements during the follow-up of a cohort
of infants with symptomatic triventricular hydrocephalus secondary to
aqueductal stenosis. Methods We performed a post hoc analysis of data
from the International Infant Hydrocephalus Study (IIHS)-a prospective,
multicenter study of infants (< 24 months old) with hydrocephalus from
aqueductal stenosis who were treated with either an ETV or shunt. During
various stages of a 5-year follow-up period, the following craniometrics
were measured: HC, HC centile, HCz-score, and frontal-occipital horn
ratio (FOR). Data were compared in an analysis of covariance, adjusting
for baseline variables including age at surgery and sex. Results Of 158
enrolled patients, 115 underwent an ETV, while 43 received a shunt. Both
procedures led to improvements in the mean HC centile position
andz-score, a trend which continued until the 5-year assessment point. A
similar trend was noted for FOR which was measured at 12 months and 3
years following initial treatment. Although the values were consistently
higher for ETV compared with shunt, the differences in HC value,
centile, andz-score were not significant. ETV was associated with a
significantly higher FOR compared with shunting at 12 months (0.52 vs
0.44;p = 0.002) and 3 years (0.46 vs 0.38;p = 0.03) of follow-up.
Conclusion ETV and shunting led to improvements in HC centile,z-score,
and FOR measurements during long-term follow-up of infants with
hydrocephalus secondary to aqueductal stenosis. Head size did not
significantly differ between the treatment groups during follow-up,
however ventricle size was greater in those undergoing ETV when measured
at 1 and 3 years following treatment."
}