@article{3194162,
    title = "Management of asthma in childhood: study protocol of a systematic
evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank",
    author = "Mathioudakis, Alexander G. and Miligkos, Michael and Boccabella, and Cristina and Alimani, Gioulinta S. and Custovic, Adnan and Deschildre, and A. and Ducharme, Francine Monique and Kalayci, Omer and Murray, Clare and and Garcia, Antonio Nieto and Phipatanakul, Wanda and Price, David and and Sheikh, Aziz and Agache, Ioana Octavia and Bacharier, Leonard and and Beloukas, Apostolos and Bentley, Andrew and Bonini, Matteo and and Castro-Rodriguez, Jose A. and De Carlo, Giuseppe and Craig, Timothy and and Diamant, Zuzana and Feleszko, Wojciech and Felton, Tim and Gern, James and E. and Grigg, Jonathan and Hedlin, Gunilla and Hossny, Elham M. and and Ierodiakonou, Despo and Jartti, Tuomas and Kaplan, Alan and Lemanske, and Robert F. and Le Souef, Peter N. and Makela, Mika J. and Mathioudakis, and Georgios A. and Matricardi, Paolo and Mitrogiorgou, Marina and and Morais-Almeida, Mario and Nagaraju, Karthik and Papageorgiou, Effie and and Pite, Helena and Pitrez, Paulo M. C. and Pohunek, Petr and Roberts, and Graham and Tsiligianni, Ioanna and Turner, Stephen and Vijverberg, and Susanne and Winders, Tonya A. and Wong, Gary W. K. and Xepapadaki, and Paraskevi and Zar, Heather J. and Papadopoulos, Nikolaos G.",
    journal = "BMJ Open Gastroenterology",
    year = "2021",
    volume = "11",
    number = "7",
    publisher = "BMJ Publishing Group",
    doi = "10.1136/bmjopen-2020-048338",
    keywords = "paediatrics; asthma; paediatric thoracic medicine; thoracic medicine",
    abstract = "Introduction Clinical recommendations for childhood asthma are often
based on data extrapolated from studies conducted in adults, despite
significant differences in mechanisms and response to treatments. The
Paediatric Asthma in Real Life (PeARL) Think Tank aspires to develop
recommendations based on the best available evidence from studies in
children. An overview of systematic reviews (SRs) on paediatric asthma
maintenance management and an SR of treatments for acute asthma attacks
in children, requiring an emergency presentation with/without hospital
admission will be conducted. Methods and analysis Standard methodology
recommended by Cochrane will be followed. Maintenance pharmacotherapy of
childhood asthma will be evaluated in an overview of SRs published after
2005 and including clinical trials or real-life studies. For evaluating
pharmacotherapy of acute asthma attacks leading to an emergency
presentation with/without hospital admission, we opted to conduct de
novo synthesis in the absence of adequate up-to-date published SRs. For
the SR of acute asthma pharmacotherapy, we will consider eligible SRs,
clinical trials or real-life studies without time restrictions. Our
evidence updates will be based on broad searches of Pubmed/Medline and
the Cochrane Library. We will use A MeaSurement Tool to Assess
systematic Reviews, V.2, Cochrane risk of bias 2 and REal Life EVidence
AssessmeNt Tool to evaluate the methodological quality of SRs,
controlled clinical trials and real-life studies, respectively. Next, we
will further assess interventions for acute severe asthma attacks with
positive clinical results in meta-analyses. We will include both
controlled clinical trials and observational studies and will assess
their quality using the previously mentioned tools. We will employ
random effect models for conducting meta-analyses, and Grading of
Recommendations Assessment, Development and Evaluation methodology to
assess certainty in the body of evidence. Ethics and dissemination
Ethics approval is not required for SRs. Our findings will be published
in peer reviewed journals and will inform clinical recommendations being
developed by the PeARL Think Tank. PROSPERO registration numbers
CRD42020132990, CRD42020171624."
}