@article{3197014,
    title = "Covid-19 Effects on ARTErial StIffness and Vascular AgeiNg: CARTESIAN
Study Rationale and Protocol",
    author = "Bruno, Rosa Maria and Spronck, Bart and Hametner, Bernhard and Hughes, and Alun and Lacolley, Patrick and Mayer, Christopher C. and Muiesan, Maria and Lorenza and Rajkumar, Chakravarthi and Terentes-Printzios, Dimitrios and and Weber, Thomas and Hansen, Tine Willum and Boutouyrie, Pierre and ARTERY and Soc",
    journal = "Artery Research",
    year = "2021",
    volume = "27",
    number = "2",
    pages = "59-68",
    publisher = "BMC",
    issn = "1872-9312",
    doi = "10.2991/artres.k.201124.001",
    keywords = "COVID-19; coronavirus; inflammation; vascular ageing; arterial stiffness",
    abstract = "In December 2019, an outbreak of pneumonia caused by a novel Coronavirus
(COVID-19) spread rapidly worldwide. Although the clinical
manifestations of COVID-19 are dominated by respiratory symptoms, the
cardiovascular system is extensively affected at multiple levels. Due to
the unprecedented consequences of the COVID-19 pandemic, the ARTERY
society decided to launch the Covid-19 effects on ARTErial StIffness and
vascular AgeiNg (CARTESIAN) study - the first international multicentre
study into the effects of COVID-19 on non-invasive biomarkers of
vascular ageing. The main study objective is to evaluate the presence of
Early Vascular Ageing (EVA) 6 and 12 months after COVID-19 infection.
Secondary objectives are to study the effect of COVID-19 disease
severity on EVA, to investigate the role of psychosocial factors in
COVID-19 induced EVA, and to investigate the potential modifying effect
of comorbidities and chronic treatments. In the CARTESIAN study, a broad
array of cardiovascular measurements, including carotid-femoral pulse
wave velocity, central blood pressure, carotid ultrasound, brachial
flow-mediated dilatation, will be performed. To date, 43 centres from 21
countries have agreed to participate, with an expected study population
of >2500 individuals. To our knowledge, CARTESIAN will be the first
study to provide insight into the relationship between COVID-19, its
severity, and early vascular ageing in a large cohort, potentially
enabling future care and diagnostics to be more focused on the most
vulnerable. (C) 2020 The Authors. Publishing services by Atlantis Press
International B.V."
}