@article{3198733,
    title = "District Differences in the Measured Values of Arterial Stiffness in Japan.",
    author = "Miyai, Nobuyuki and Uchiba, Kiyoshi and Tomiyama, Hirofumi and Matsumoto, Chisa and Kinoshita, Azuna and Vlachoupolos, Charalambos and Nilsson, Peter M. and Arita, Mikio",
    journal = "Circulation reports",
    year = "2021",
    volume = "3",
    number = "10",
    pages = "620--624",
    doi = "10.1253/circrep.CR-21-0064",
    keywords = "Epidemiology, Arterial stiffness, Cardiovascular disease, Elderly people",
    abstract = "Background: In Japan, district differences in the prevalence of cardiovascular disease (CVD) are well-known. This study examined district differences in Japan in  measured values of arterial stiffness, an independent risk factor for CVD.  Methods and Results: Local residents participating in health checkups conducted in  the Wakayama (n=461) and Nagano (n=186) prefectures in 2018 were recruited to the  study. Brachial-ankle pulse wave velocity (baPWV) was evaluated as an index of  arterial stiffness. After multivariate adjustment, baPWV was significantly higher in  the Wakayama than Nagano district in subjects aged ≥70 years (mean [±SE] 1,912±25  vs. 1,763±30 cm/s; P{\textless}0.01), but not in subjects aged {\textless}70 years. Multivariate linear  regression analysis demonstrated that the Wakayama/Nagano district difference was  significantly (P{\textless}0.01) associated with baPWV. Conclusions: District differences were  observed in the measured values of arterial stiffness in Wakayama and Nagano. The  Wakayama and Nagano prefectures are representative areas with a relatively high and  relatively low prevalence of CVD, respectively, in Japan. Therefore, based on the  results of the present study, we propose to conduct a study to examine whether  district differences in arterial stiffness underlie district differences in the  prevalence of CVD."
}