@article{3201711,
    title = "Off-label intravenous thrombolysis for early recurrent brain embolism associated with aortic arch thrombus.",
    author = "Koutroulou, Ioanna and Tsivgoulis, Georgios and Rafailidis, Vasileios and Psoma, Elissavet and Kouskouras, Konstantinos and Fotiadis, Panagiotis and Grigoriadis, Nikolaos and Karapanayiotides, Theodoros",
    journal = "Neurological research and practice",
    year = "2021",
    volume = "3",
    number = "1",
    pages = "4",
    doi = "10.1186/s42466-021-00103-6",
    keywords = "Aortic arch thrombus, Brain embolism, Off-label thrombolysis, Stroke",
    abstract = "Safety data of intravenous thrombolysis (IVT) in presence of aortic arch thrombus is scant. Furthermore, IVT is debatable in patients with prior recent stroke. We  present a 51-year-old woman with recurrent major infarction 5 days after a minor  left MCA territory stroke. She had a floating aortic arch thrombus and she was  treated safely and effectively with off-label IVT. Patients with small infarct  volumes and mild/no residual neurological deficits after an initial stroke might be  considered for IVT in case of early recurrence. IVT may be reasonable in a context  of acute severely disabling stroke associated with aortic arch thrombus."
}