@article{3203701,
    title = "Consensus Guidelines for the Definition of Time-to-Event End Points in Image-guided Tumor Ablation: Results of the SIO and DATECAN Initiative.",
    author = "Puijk, Robbert S. and Ahmed, Muneeb and Adam, Andreas and Arai, Yasuaki and Arellano, Ronald and de Baère, Thierry and Bale, Reto and Bellera, Carine and Binkert, Christoph A. and Brace, Christopher L. and Breen, David J. and Brountzos, Elias and Callstrom, Matthew R. and Carrafiello, Gianpaolo and Chapiro, Julius and de Cobelli, Francesco and Coupé, Veerle M. H. and Crocetti, Laura and Denys, Alban and Dupuy, Damian E. and Erinjeri, Joseph P. and Filippiadis, Dimitris and Gangi, Afshin and Gervais, Debra A. and Gillams, Alice R. and Greene, Tissy and Guiu, Boris and Helmberger, Thomas and Iezzi, Roberto and Kang, Tae Wook and Kelekis, Alexis and Kim, Hyun S. and Kröncke, Thomas and Kwan, Sharon and Lee, Min Woo and Lee, Fred T. and Lee, Edward W. Jr and Liang, Ping and Lissenberg-Witte, Birgit I. and Lu, David S. and Madoff, David C. and Mauri, Giovanni and Meloni, Maria Franca and Morgan, Robert and Nadolski, Gregory and Narayanan, Govindarajan and Newton, Isabel and Nikolic, Boris and Orsi, Franco and Pereira, Philippe L. and Pua, Uei and Rhim, Hyunchul and Ricke, Jens and Rilling, William and Salem, Riad and Scheffer, Hester J. and Sofocleous, Constantinos T. and Solbiati, Luigi A. and Solomon, Stephen B. and Soulen, Michael C. and Sze, Daniel and Uberoi, Raman and Vogl, Thomas J. and Wang, David S. and Wood, Bradford J. and Goldberg, S. Nahum and Meijerink, Martijn R.",
    journal = "Dentomaxillofacial Radiology",
    year = "2021",
    volume = "301",
    number = "3",
    pages = "533--540",
    doi = "10.1148/radiol.2021203715",
    keywords = "Humans, Reproducibility of Results, Consensus, Societies, Medical, Ablation Techniques/*methods, Neoplasms/*surgery",
    abstract = "There is currently no consensus regarding preferred clinical outcome measures following image-guided tumor ablation or clear definitions of oncologic end points.  This consensus document proposes standardized definitions for a broad range of  oncologic outcome measures with recommendations on how to uniformly document,  analyze, and report outcomes. The initiative was coordinated by the Society of  Interventional Oncology in collaboration with the Definition for the Assessment of  Time-to-Event End Points in Cancer Trials, or DATECAN, group. According to  predefined criteria, based on experience with clinical trials, an international  panel of 62 experts convened. Recommendations were developed using the validated  three-step modified Delphi consensus method. Consensus was reached on when to assess  outcomes per patient, per session, or per tumor; on starting and ending time and  survival time definitions; and on time-to-event end points. Although no consensus  was reached on the preferred classification system to report complications, quality  of life, and health economics issues, the panel did agree on using the most recent  version of a validated patient-reported outcome questionnaire. This article provides  a framework of key opinion leader recommendations with the intent to facilitate a  clear interpretation of results and standardize worldwide communication. Widespread  adoption will improve reproducibility, allow for accurate comparisons, and avoid  misinterpretations in the field of interventional oncology research. Published under  a CC BY 4.0 license. Online supplemental material is available for this article. See  also the editorial by Liddell in this issue."
}