@article{3203984,
    title = "A Role for Sox2 in the Adult Cerebellum.",
    author = "Mandalos, Nikolaos Panagiotis and Karampelas, Ioannis and Saridaki, Marannia and McKay, Ronald D. G. and Cohen, Mark L. and Remboutsika, Eumorphia",
    journal = "Journal of stem cell research & therapy",
    year = "2018",
    volume = "8",
    number = "7",
    pages = "433",
    doi = "10.4172/2157-7633.1000433",
    keywords = "*Neurodegeneration, *Development, *Differentiation, *Neural progenitor cells, *Neural stem cells, *Neurogenesis, *Sox genes",
    abstract = "The cerebellum, a derivative of the hindbrain, plays a crucial role in balance and posture as well as in higher cognitive and locomotive processes. Cerebellar  development is initiated during the segmental phase of hindbrain formation. Here, we  describe the phenotype, of a single surviving adult conditional mouse mutant mouse,  in which Sox2 function is ablated in embryonic radial glial cells by means of  hGFAP-CRE. The single Sox2(RGINV/mosaic) adult mutant mouse displays motor  disability, microsomia, reduced Central Nervous System (CNS) size and cerebellar  defects associated with human genetically related congenital abnormalities."
}