@article{3219599,
    title = "Losartan Interactions with 2-Hydroxypropyl-β-CD",
    author = "Palli, V. and Leonis, G. and Zoupanou, N. and Georgiou, N. and Chountoulesi, M. and Naziris, N. and Tzeli, D. and Demetzos, C. and Valsami, G. and Marousis, K.D. and Spyroulias, G.A. and Mavromoustakos, T.",
    journal = "Molecules (Basel, Switzerland)",
    year = "2022",
    volume = "27",
    number = "8",
    publisher = "MDPI",
    doi = "10.3390/molecules27082421",
    keywords = "2 hydroxypropyl beta cyclodextrin;  antihypertensive agent;  hydroxypropylmethylcellulose;  losartan, chemistry;  differential scanning calorimetry;  freeze drying;  human;  solubility, 2-Hydroxypropyl-beta-cyclodextrin;  Antihypertensive Agents;  Calorimetry, Differential Scanning;  Freeze Drying;  Humans;  Hypromellose Derivatives;  Losartan;  Solubility",
    abstract = "Losartan potassium salt (LSR) is a well-known antihypertensive drug with proven beneficial effects on human health. Its formulation with the non-toxic 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD) could improve its pharmacological profile. Thus, its molecular interactions are studied using a combination of Differential Scanning Calorimetry (DSC), Nuclear Magnetic Resonance (NMR) and Molecular Dynamics (MD). First, its complexation is shown through Differential Scanning Calorimetry as lyophilization provided distinct thermal properties in comparison to the mixture. The complexation is further proved by utilizing the chemical shift changes in the complexation and T1 values. Furthermore, the reversible favorable complexation was shown by MD calculations. Such physical chemical properties provide evidence that this formulation must be further explored through biological experiments. © 2022 by the authors. Licensee MDPI, Basel, Switzerland."
}