@article{3220286,
    title = "Trained immunity in viral infections, Alzheimer's disease and multiple sclerosis: A convergence in type I interferon signalling and IFNβ-1a",
    author = "Vavougios, G.D. and Mavridis, T. and Artemiadis, A. and Krogfelt, K.A. and Hadjigeorgiou, G.",
    journal = "Biochimica et Biophysica Acta.  Molecular Basis of Disease",
    year = "2022",
    volume = "1868",
    number = "9",
    publisher = "Elsevier B.V.",
    issn = "0925-4439",
    doi = "10.1016/j.bbadis.2022.166430",
    abstract = "Type I interferon (IFN-I) signalling represents a major target for modulation in a virus' bid for latency. IFN-I perturbations are also present in such as Alzheimer's disease (AD) and multiple sclerosis (MS), where viral infections are known to increase symptomatic burden. IFN-I modulation such as via IFNβ-1a, an established MS treatment, has been researched to a limited extent to both AD and COVID-19. In this mini review, we present emerging research on trained immunity as a pathogenetic basis for Alzheimer's disease and the emerging context for IFNβ-1a repositioning, via mechanisms shared with multiple sclerosis and induced by viral infections. © 2022 Elsevier B.V."
}