@article{3220381,
    title = "Bisphenol A correlates with fewer retrieved oocytes in women with tubal factor infertility",
    author = "Mina, A. and Boutzios, G. and Papoutsis, I. and Kaparos, G. and Christopoulos, P. and Kousta, E. and Mastrominas, M. and Athanaselis, S. and Mastorakos, G.",
    journal = "Vitamins and Hormones",
    year = "2022",
    volume = "21",
    number = "2",
    pages = "305-315",
    publisher = "Springer Science and Business Media Deutschland GmbH",
    doi = "10.1007/s42000-022-00370-1",
    keywords = "4,4' isopropylidenediphenol;  benzhydryl derivative;  phenol derivative, complication;  cross-sectional study;  female;  female infertility;  human;  obesity;  oocyte;  ovary polycystic disease;  pregnancy, Benzhydryl Compounds;  Cross-Sectional Studies;  Female;  Humans;  Infertility, Female;  Obesity;  Oocytes;  Overweight;  Phenols;  Polycystic Ovary Syndrome;  Pregnancy",
    abstract = "Purpose: Serum and urinary bisphenol A (BPA) concentrations have been associated negatively with the number of retrieved oocytes after in vitro fertilization (IVF). The impact of BPA upon women with polycystic ovary syndrome (PCOS) and women with tubal factor infertility (TFI), following IVF, was investigated. To this purpose, associations among serum and urinary and follicular fluid (FF) BPA concentrations and the number of retrieved and fertilized oocytes and comparisons between pregnancy rates were evaluated. Methods: This was a cross-sectional study conducted at a university-affiliated assisted conception unit between January and November 2019, including 93 women of reproductive age (PCOS: 45; TFI: 48) following IVF. Unconjugated FF and serum BPA concentrations and total urinary BPA concentration were measured using a novel gas chromatography–mass spectrometry method. The number of retrieved and fertilized oocytes and pregnancy rate were documented and evaluated. Results: The number of oocytes retrieved from PCOS women was greater than that of 21 TFI women, independently of BMI. Lower FF BPA concentrations were found in all PCOS women and in overweight/obese PCOS compared to TFI women (0.50, 0.38, and 1.13 ng/mL, respectively). In TFI women, FF BPA concentrations correlated negatively with the number of retrieved oocytes. Serum and FF and urinary BPA concentrations did not significantly affect the number of fertilized oocytes and pregnancy rate in both groups. Conclusion: FF BPA concentrations were lower in all PCOS women and in overweight/obese PCOS than in TFI women. In TFI women, FF BPA concentrations correlated negatively with retrieved oocytes. Confirmation of these findings might lead to moderation of use of BPA-containing products by women undergoing IVF. © 2022, Hellenic Endocrine Society."
}