@article{3220883, title = "Optical coherence tomography in coronary atherosclerosis assessment and intervention", author = "Araki, M. and Park, S.-J. and Dauerman, H.L. and Uemura, S. and Kim, J.-S. and Di Mario, C. and Johnson, T.W. and Guagliumi, G. and Kastrati, A. and Joner, M. and Holm, N.R. and Alfonso, F. and Wijns, W. and Adriaenssens, T. and Nef, H. and Rioufol, G. and Amabile, N. and Souteyrand, G. and Meneveau, N. and Gerbaud, E. and Opolski, M.P. and Gonzalo, N. and Tearney, G.J. and Bouma, B. and Aguirre, A.D. and Mintz, G.S. and Stone, G.W. and Bourantas, C.V. and Räber, L. and Gili, S. and Mizuno, K. and Kimura, S. and Shinke, T. and Hong, M.-K. and Jang, Y. and Cho, J.M. and Yan, B.P. and Porto, I. and Niccoli, G. and Montone, R.A. and Thondapu, V. and Papafaklis, M.I. and Michalis, L.K. and Reynolds, H. and Saw, J. and Libby, P. and Weisz, G. and Iannaccone, M. and Gori, T. and Toutouzas, K. and Yonetsu, T. and Minami, Y. and Takano, M. and Raffel, O.C. and Kurihara, O. and Soeda, T. and Sugiyama, T. and Kim, H.O. and Lee, T. and Higuma, T. and Nakajima, A. and Yamamoto, E. and Bryniarski, K.L. and Di Vito, L. and Vergallo, R. and Fracassi, F. and Russo, M. and Seegers, L.M. and McNulty, I. and Park, S. and Feldman, M. and Escaned, J. and Prati, F. and Arbustini, E. and Pinto, F.J. and Waksman, R. and Garcia-Garcia, H.M. and Maehara, A. and Ali, Z. and Finn, A.V. and Virmani, R. and Kini, A.S. and Daemen, J. and Kume, T. and Hibi, K. and Tanaka, A. and Akasaka, T. and Kubo, T. and Yasuda, S. and Croce, K. and Granada, J.F. and Lerman, A. and Prasad, A. and Regar, E. and Saito, Y. and Sankardas, M.A. and Subban, V. and Weissman, N.J. and Chen, Y. and Yu, B. and Nicholls, S.J. and Barlis, P. and West, N.E.J. and Arbab-Zadeh, A. and Ye, J.C. and Dijkstra, J. and Lee, H. and Narula, J. and Crea, F. and Nakamura, S. and Kakuta, T. and Fujimoto, J. and Fuster, V. and Jang, I.-K.", journal = "Nature Reviews Cardiology", year = "2022", publisher = "Lithuanian Nature Research Centre", issn = "1759-5002, 1759-5010", doi = "10.1038/s41569-022-00687-9", abstract = "Since optical coherence tomography (OCT) was first performed in humans two decades ago, this imaging modality has been widely adopted in research on coronary atherosclerosis and adopted clinically for the optimization of percutaneous coronary intervention. In the past 10 years, substantial advances have been made in the understanding of in vivo vascular biology using OCT. Identification by OCT of culprit plaque pathology could potentially lead to a major shift in the management of patients with acute coronary syndromes. Detection by OCT of healed coronary plaque has been important in our understanding of the mechanisms involved in plaque destabilization and healing with the rapid progression of atherosclerosis. Accurate detection by OCT of sequelae from percutaneous coronary interventions that might be missed by angiography could improve clinical outcomes. In addition, OCT has become an essential diagnostic modality for myocardial infarction with non-obstructive coronary arteries. Insight into neoatherosclerosis from OCT could improve our understanding of the mechanisms of very late stent thrombosis. The appropriate use of OCT depends on accurate interpretation and understanding of the clinical significance of OCT findings. In this Review, we summarize the state of the art in cardiac OCT and facilitate the uniform use of this modality in coronary atherosclerosis. Contributions have been made by clinicians and investigators worldwide with extensive experience in OCT, with the aim that this document will serve as a standard reference for future research and clinical application. © 2022, Springer Nature Limited." }