TY - CONF
TI - EXPLORATION OF DIETARY PLANTS FROM WORLDWIDE BIODIVERSITY AIMING THE DISCOVERY OF ACTIVE AGENTS WITH ANTI-AGEING EFFECTS
AU - Maria-Eleni Sakavitsi
AU - Zoi Evangelakou
AU - Gabriela Belen Lemus Ringele
AU - Amal Ghorbel
AU - Aikaterini Argyropoulou
AU -  Victor Kesternich
AU -  Noureddine Allouche
AU - Ioannis Trougakos
AU - Maria Halabalaki
AU - Leandros Skaltsounis
PY - 2017
SP - Proceedings PP192
PB - European Commission
T2 - 3rd International Conference on Natural Products Utilization (ICNPU), Bansko, Bulgaria, October 18-21, 2017.
TODO - null
TODO - Aristotelia chilensis, Ceratonia siliqua, antioxidant, anti-ageing, nutraceuticals
TODO - Dietary interventions obtain a profound impact on human lifespan, while constitute edible plants a promising source of chemical entities that promotes healthy ageing1. Maqui (Aristotelia chilensis, Elaeocarpaceae [Molina] Stunz), is a small tree native to South Chile, deeply rooted in traditional dietary culture of indigenous. Moreover, carob tree (Ceratonia siliqua, Leguminosae L.) has been grown since antiquity in most countries of Mediterranean region, composing a staple in the diet of people in times of famine. Maqui berries and carob pods, have drawn attention due to their potential health benefits, which are largely attributed to their rich polyphenolic content. 
A high-throughput phytochemical investigation of methanol and water extracts of the edible parts, berries and pods respectively, was performed. Fingerprinting procedures using HPTLC showed that both plants had rich chemical profile, while phenolic compounds prevailed. Profiling and dereplication procedures employing hyphenated techniques (HPLC/UHPLC-PDA, LC-(ESI)-HRMS/MS) were also applied and various putative bioactive compounds were identified. Hence, analytical and preparative techniques afforded compounds belonging to anthocyanins, flavonoids, flavonoid glucosides and phenolic acids, followed by structure elucidation (1D & 2D NMR). The in vivo evaluation of anti-oxidant and anti-ageing properties of maqui and carob pods water extracts in Drosophila melanogaster flies revealed, that oral administration of both activate the Nrf2/Keap1 antioxidant pathway and proteasome peptidase activities. Complementary to the above, the metabolism of both dietary fruit extracts was investigated in vitro using rat liver microsomes. Conclusively, maqui and carob pod water extracts could be a potent source of anti-oxidant/ anti-ageing nutraceuticals.
ER -