TY - JOUR
TI - Efforts to understand the molecular basis of hypertension through drug:membrane interactions
AU - T Mavromoustakos
AU - P Zoumpoulakis
AU - I Kyrikou
AU - A Zoga
AU - E Siapi
AU - M Zervou
AU - I Daliani
AU - D Dimitriou
AU - A Pitsas
AU - C Kamoutsis
AU - P Laggner
JO - Current Topics in Medicinal Chemistry
PY - 2004
VL - 4
TODO - 4
SP - 445-59
PB - Bentham Science Publishers Ltd
SN - 1568-0266
TODO - 10.2174/1568026043451339
TODO - -
TODO - Biological membranes play an essential role in the drug action. They constitute the first barrier for drugs to exert their biological action. AT1 antagonists are amphiphilic molecules and are hypothesized to act on AT1 receptor through incorporation (first step) and lateral diffusion through membrane bilayers (second step). Various biophysical methods along with Molecular Modelling were applied in order to explore the plausible two step proposed mechanism of action for this class of antihypertensive drugs.
ER -