TY - JOUR
TI - Exploring the interactions of irbesartan-2-hydroxypropyl-β-cyclodextrin complex in micelles
AU - T. Mavromoustakos, D. Ntountaniotis, G. Leonis, E. Christodoulou
JO - Journal of International Scientific Publications
PY - 2017
VL - 13
TODO - -
SP - 270-278
PB - Elsevier
SN - 1314-7269
TODO - null
TODO - irbesartan, 2-hydroxypropyl-cyclodextrin, sodium dodecyl sulfate, micelles, NMR spectroscopy
TODO - Irbesartan is a beneficial drug against hypertension and other diseases. Although it is a polydynamic drug, it
suffers from high lipophilicity. New formulations of the drug may increase its efficient pharmacological
profile. Towards this aim, we have studied the interactions of irbesartan in simple or complexed form with 2-
hydroxypropyl-cyclodextrin in micelles. The interactions of the drug in the two forms in the micelle
environment are discussed. Of special interest, is the highly flexibility of the spacer phenyl ring
ER -