TY - JOUR
TI - pHEMA@AGMNA-1: A novel material for the development of antibacterial contact lens
AU - A.K. Rossos, C.N. Bantia, A. Kalampounias, C. Papachristodoulou, K. Kordatos, P. Zoumpoulakis, T. Mavromoustakos, N. Kourkoumelis, S.K. Hadjikakou
JO - Materials Science and Engineering C: Biomimetic and Supramolecular Systems
PY - 2020
VL - 111
TODO - -
SP - 110770
PB - Elsevier
SN - 0928-4931
TODO - https://doi.org/10.1016/j.msec.2020.110770
TODO - Antimicrobial materials Hydrogels Antibacterial active contact lens Microbial keratitis
TODO - The Metal Organic Framework (MOF) of formula {[Ag6(μ3-HMNA)4(μ3-MNA)2]2−·[(Et3NH)+]2·(DMSO)2·(H2O)} (AGMNA), a known efficient antimicrobial compound which contains the anti-metabolite, 2-thio-nicotinic acid (H2MNA), was incorporated in polymer hydrogels using, hydroxyethyl-methacrylate (HEMA). The material pHEMA@AGMNA-1 was characterized by X-ray fluorescence (XRF) spectroscopy, X-ray powder diffraction analysis (XRPD), Scanning Electron Microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDX), Thermogravimetric Differential Thermal Analysis (TG-DTA), Differential Scanning Calorimetry (DTG/DSC), attenuated total reflection spectroscopy (FT-IR-ATR) and Ultrasonic Imaging. The antimicrobial capacity of pHEMA@AGMNA-1 was evaluated against the Gram negative bacterial strain Pseudomonas aeruginosa and the Gram positive ones of the genus of Staphylococcus epidermidis and Staphylococcus aureus, which are the etiology of the microbial keratitis. The % bacterial viability of P. aeruginosa, S. epidermidis and S. aureus upon their incubation with pHEMA@AGMNA-1 discs is significantly low (0.4 ± 0.1%, 1.5 ± 0.4% and 7.7 ± 0.5% respectively). The inhibition zones (IZ) caused by pHEMA@AGMNA-1 discs against P. aeruginosa, S. epidermidis and S. aureus are 14.0 ± 1.1, 11.3 ± 1.3 and 11.8 ± 1.8 mm respectively. Furthermore, pHEMA@AGMNA-1 exhibits low toxicity. Thus, pHEMA@AGMNA-1 might be an efficient candidate for the development of antimicrobial active contact lenses.
ER -