TY - JOUR
TI - mTOR Signaling Components in Tumor Mechanobiology
AU - Gargalionis, A.N.
AU - Papavassiliou, K.A.
AU - Basdra, E.K.
AU - Papavassiliou, A.G.
JO - International Journal of Molecular Sciences
PY - 2022
VL - 23
TODO - 3
SP - null
PB - MDPI
SN - 1422-0067
TODO - 10.3390/ijms23031825
TODO - null
TODO - Mechanistic target of rapamycin (mTOR) is a central signaling hub that integrates networks of nutrient availability, cellular metabolism, and autophagy in eukaryotic cells. mTOR kinase, along with its upstream regulators and downstream substrates, is upregulated in most human malignancies. At the same time, mechanical forces from the tumor microenvironment and mechanotransduction promote cancer cells’ proliferation, motility, and invasion. mTOR signaling pathway has been recently found on the crossroads of mechanoresponsive-induced signaling cascades to regulate cell growth, invasion, and metastasis in cancer cells. In this review, we examine the emerging association of mTOR signaling components with certain protein tools of tumor mechanobiology. Thereby, we highlight novel mechanisms of mechanotransduction, which regulate tumor progression and invasion, as well as mechanisms related to the therapeutic efficacy of antitumor drugs. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
ER -