TY - JOUR
TI - Maltreatment, the oxytocin receptor gene, and conduct problems among male and female teenagers
AU - Andreou, D.
AU - Comasco, E.
AU - Åslund, C.
AU - Nilsson, K.W.
AU - Hodgins, S.
JO - Frontiers in Human Neuroscience
PY - 2018
VL - 12
TODO - null
SP - null
PB - Frontiers Media S. A
SN - null
TODO - 10.3389/fnhum.2018.00112
TODO - oxytocin receptor, adolescent;  adolescent behavior;  adult;  allele;  antisocial behavior;  antisocial personality disorder;  Article;  behavior disorder;  child abuse;  comparative study;  controlled study;  disease association;  DNA extraction;  female;  genotype;  human;  male;  OXTR gene;  saliva analysis;  self report
TODO - The oxytocin receptor gene (OXTR) influences human behavior. The G allele of OXTR rs53576 has been associated with both prosocial and maladaptive behaviors but few studies have taken account of environmental factors. The present study determined whether the association of childhood maltreatment with conduct problems was modified by OXTR rs53576 genotypes. In a general population sample of 1591 teenagers, conduct problems as well as maltreatment were measured by self-report. DNA was extracted from saliva samples. In males, there was a significant positive association between maltreatment and conduct problems independent of the genotype. In females, among G allele carriers, the level of conduct problems was significantly higher among those who had been maltreated as compared to those not maltreated. By contrast, among female AA carriers, conduct problems did not vary between those who were, and who were not, maltreated. The results indicate that OXTR rs53576 plays a role in antisocial behavior in females such that the G allele confers vulnerability for antisocial behavior if they experience maltreatment, whereas the A allele has a protective effect. © 2018 Andreou, Comasco, Åslund, Nilsson and Hodgins.
ER -