TY - JOUR
TI - Brief report: "Allergic symptoms" in children with autism spectrum disorders. more than meets the eye?
AU - Angelidou, A.
AU - Alysandratos, K.-D.
AU - Asadi, S.
AU - Zhang, B.
AU - Francis, K.
AU - Vasiadi, M.
AU - Kalogeromitros, D.
AU - Theoharides, T.C.
JO - Journal of Autism and Developmental Disorders
PY - 2011
VL - 41
TODO - 11
SP - 1579-1585
PB - 
SN - 0162-3257, 1573-3432
TODO - 10.1007/s10803-010-1171-z
TODO - corticotropin releasing factor;  immunoglobulin E;  monocyte chemotactic protein 1;  neurotensin;  toll like receptor 3;  toll like receptor 4;  transforming growth factor beta1, adaptive immunity;  allergy;  article;  asthma;  atopic dermatitis;  autism;  blood brain barrier;  cell activation;  cell function;  cerebrospinal fluid analysis;  disease association;  disease severity;  encephalitis;  environmental exposure;  family history;  food allergy;  human;  immune system;  immunoglobulin blood level;  infection;  innate immunity;  intestine;  intestine mucosa permeability;  mast cell;  mastocytosis;  neurotoxicity;  nutritional intolerance;  observational study;  priority journal;  protein binding;  rhinitis;  skin allergy;  skin test;  skin tingling;  stress;  urticaria;  wheezing, Brain;  Child;  Child Development Disorders, Pervasive;  Humans;  Hypersensitivity;  Mast Cells;  Mastocytosis;  Risk Factors
TODO - Many children with Autism Spectrum Disorders (ASD) have either family and/or personal history of "allergic symptomatology", often in the absence of positive skin or RAST tests. These symptoms may suggest mast cell activation by non-allergic triggers. Moreover, children with mastocytosis or mast cell activation syndrome (MCAS), a spectrum of rare diseases characterized by increased number of activated mast cells in many organs, appear to have ASD at a rate tenfold higher (1/10 children) than that of the general population (1/100 children). Mast cell activation by allergic, infectious, environmental and stress-related triggers, especially perinatally, would release pro-inflammatory and neurotoxic molecules. We speculate these could disrupt the gut-blood-brain barriers, thus contributing to brain inflammation and ASD pathogenesis. Increased mast cell responsiveness may define at least a subgroup of ASD subjects, who could benefit from inhibition of mast cell activation. © 2011 Springer Science+Business Media, LLC.
ER -