TY - JOUR
TI - Slight and short-lasting increase of serum S-100B protein in extra-cranial trauma
AU - Korfias, S.
AU - Stranjalis, G.
AU - Psachoulia, C.
AU - Vasiliadis, C.
AU - Pitaridis, M.
AU - Boviatsis, E.
AU - Sakas, D.E.
JO - Brain Injury Journey Magazine
PY - 2006
VL - 20
TODO - 8
SP - 867-872
PB - Informa Healthcare
SN - null
TODO - 10.1080/02699050600832395
TODO - biological marker;  protein S100B, abdominal injury;  adult;  aged;  article;  controlled study;  correlation analysis;  female;  fracture;  human;  injury severity;  major clinical study;  male;  postoperative period;  protein blood level;  protein secretion;  rank sum test;  surgical injury;  thorax injury;  traumatic brain injury;  Wilcoxon signed ranks test
TODO - Objective: Serum S-100B protein is an established biochemical marker of traumatic brain injury. At the same time, the question of extra-cranial S-100B release has been raised. This study evaluates the post-traumatic and post-operative release kinetics of S-100B in 45 trauma victims without head injury. Method: Serum S-100B protein was measured on admission and every 24 hours for 4 consecutive days. Results: Initial S-100B was slightly increased (median: 0.54 μg L-1) and correlated with the severity of extra-cranial trauma (p = 0.0004, Mann-Whitney test). Both severely (abdominal or chest trauma with or without bone fractures) and mildly (long bone fractures) injured showed a rapid decline of S-100B (<0.2 μg L-1) around 72 hours post-trauma. Extra-cranial surgery caused a secondary increase of S-100B, especially in the mildly injured group (p = 0.004, Wilcoxon signed rankest). Conclusions: Extra-cranial injury results in a mild elevation of serum S-100B protein that declines rapidly (1-3 days after injury).
ER -