TY - JOUR
TI - Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection
AU - Saccone, G.
AU - Sen, C.
AU - Di Mascio, D.
AU - Galindo, A.
AU - Grünebaum, A.
AU - Yoshimatsu, J.
AU - Stanojevic, M.
AU - Kurjak, A.
AU - Chervenak, F.
AU - Suárez, M.J.R.
AU - Gambacorti-Passerini, Z.M.
AU - de los Angeles Anaya Baz, M.
AU - Galán, E.V.A.
AU - López, Y.C.
AU - Luis, J.A.D.L.
AU - Hernández, I.C.
AU - Herraiz, I.
AU - Villalain, C.
AU - Venturella, R.
AU - Rizzo, G.
AU - Mappa, I.
AU - Gerosolima, G.
AU - Hellmeyer, L.
AU - Königbauer, J.
AU - Ameli, G.
AU - Frusca, T.
AU - Volpe, N.
AU - Schera, G.B.L.
AU - Fieni, S.
AU - Esposito, E.
AU - Simonazzi, G.
AU - Di Donna, G.
AU - Youssef, A.
AU - Gatta, A.N.D.
AU - Di Donna, M.C.
AU - Chiantera, V.
AU - Buono, N.
AU - Sozzi, G.
AU - Greco, P.
AU - Morano, D.
AU - Bianchi, B.
AU - Marino, M.G.L.
AU - Laraud, F.
AU - Ramone, A.
AU - Cagnacci, A.
AU - Barra, F.
AU - Gustavino, C.
AU - Ferrero, S.
AU - Ghezzi, F.
AU - Cromi, A.
AU - Laganà, A.S.
AU - Longo, V.L.
AU - Stollagli, F.
AU - Sirico, A.
AU - Lanzone, A.
AU - Driul, L.
AU - Cecchini, F.
AU - Xodo, S.
AU - Rodriguez, B.
AU - Mercado-Olivares, F.
AU - Elkafrawi, D.
AU - Sisti, G.
AU - Esposito, R.
AU - Coviello, A.
AU - Cerbone, M.
AU - Morlando, M.
AU - Schiattarella, A.
AU - Colacurci, N.
AU - De Franciscis, P.
AU - Cataneo, I.
AU - Lenzi, M.
AU - Sandri, F.
AU - Buscemi, R.
AU - Gattei, G.
AU - Sala, F.D.
AU - Valori, E.
AU - Rovellotti, M.C.
AU - Done, E.
AU - Faron, G.
AU - Gucciardo, L.
AU - Esposito, V.
AU - Vena, F.
AU - Giancotti, A.
AU - Brunelli, R.
AU - Muzii, L.
AU - Nappi, L.
AU - Sorrentino, F.
AU - Liberati, M.
AU - Buca, D.
AU - Leombroni, M.
AU - Di Sebastiano, F.
AU - Franchi, M.
AU - Ianniciello, Q.C.
AU - Garzon, S.
AU - Petriglia, G.
AU - Borrello, L.
AU - Nieto-Calvache, A.J.
AU - Burgos-Luna, J.M.
AU - Kadji, C.
AU - Carlin, A.
AU - Bevilacqua, E.
AU - Moucho, M.
AU - Viana Pinto, P.
AU - Figueiredo, R.
AU - Morales Roselló, J.
AU - Loscalzo, G.
AU - Martinez-Varea, A.
AU - Diago, V.
AU - Jimenez Lopez, J.S.
AU - Aykanat, A.Y.
AU - Cosma, S.
AU - Carosso, A.
AU - Benedetto, C.
AU - Bermejo, A.
AU - Feuerschuette, O.H.M.
AU - Uyaniklar, O.
AU - Ocakouglu, S.R.
AU - Atak, Z.
AU - Gündüz, R.
AU - Haberal, E.T.
AU - Froessler, B.
AU - Parange, A.
AU - Palm, P.
AU - Samardjiski, I.
AU - Taccaliti, C.
AU - Okuyan, E.
AU - Daskalakis, G.
AU - de Sa, R.A.M.
AU - Pittaro, A.
AU - Gonzalez-Duran, M.L.
AU - Guisan, A.C.
AU - Genç, S.Ö.
AU - Zlatohlávková, B.
AU - Piqueras, A.L.
AU - Oliva, D.E.
AU - Cil, A.P.
AU - Api, O.
AU - Antsaklis, P.
AU - Ples, L.
AU - Kyvernitakis, I.
AU - Maul, H.
AU - Malan, M.
AU - Lila, A.
AU - Granese, R.
AU - Ercoli, A.
AU - Zoccali, G.
AU - Villasco, A.
AU - Biglia, N.
AU - Madalina, C.
AU - Costa, E.
AU - Daelemans, C.
AU - Pintiaux, A.
AU - Cueto, E.
AU - Hadar, E.
AU - Dollinger, S.
AU - Brzezinski-Sinai, N.A.
AU - Huertas, E.
AU - Arango, P.
AU - Sanchez, A.
AU - Schvartzman, J.A.
AU - Cojocaru, L.
AU - Turan, S.
AU - Turan, O.
AU - Di Dedda, M.C.
AU - Molpeceres, R.G.
AU - Zdjelar, S.
AU - Premru-Srsen, T.
AU - Kornhauser-Cerar, L.
AU - Druškovic, M.
AU - De Robertis, V.
AU - Stefanovic, V.
AU - Nupponen, I.
AU - Nelskylä, K.
AU - Khodjaeva, Z.
AU - Gorina, K.A.
AU - Sukhikh, G.T.
AU - Maruotti, G.M.
AU - Visentin, S.
AU - Cosmi, E.
AU - Ferrari, J.
AU - Gatti, A.
AU - Luvero, D.
AU - Angioli, R.
AU - Puri, L.
AU - Palumbo, M.
AU - D'Urso, G.
AU - Colaleo, F.
AU - Rapisarda, A.M.C.
AU - Carbone, I.F.
AU - Manzoli, L.
AU - Flacco, M.E.
AU - Nazzaro, G.
AU - Locci, M.
AU - Guida, M.
AU - Sardo, A.D.S.
AU - Panici, P.B.
AU - Khalil, A.
AU - Berghella, V.
AU - Bifulco, G.
AU - Scambia, G.
AU - Zullo, F.
AU - D'Antonio, F.
AU - The WAPM (World Association of Perinatal Medicine) Working Group on COVID-19
JO - Ultrasound in Obstetrics and Gynecology
PY - 2021
VL - 57
TODO - 2
SP - 232-241
PB - John Wiley and Sons Ltd
SN - 0960-7692, 1469-0705
TODO - 10.1002/uog.23107
TODO - adult;  artificial ventilation;  cohort analysis;  diagnosis;  female;  genetics;  hospitalization;  human;  infant;  intensive care unit;  isolation and purification;  maternal mortality;  mortality;  newborn;  pandemic;  pregnancy;  pregnancy complication;  pregnancy outcome;  retrospective study;  virology, Adult;  Cohort Studies;  COVID-19;  Female;  Hospitalization;  Humans;  Infant;  Infant, Newborn;  Intensive Care Units;  Maternal Mortality;  Pandemics;  Pregnancy;  Pregnancy Complications, Infectious;  Pregnancy Outcome;  Respiration, Artificial;  Retrospective Studies;  SARS-CoV-2
TODO - Objectives: To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods: This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results: In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251 (27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions: SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. © 2020 International Society of Ultrasound in Obstetrics and Gynecology. © 2020 International Society of Ultrasound in Obstetrics and Gynecology
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