TY - JOUR TI - Physical activity frequency on the 10-year acute coronary syndrome (ACS) prognosis; The interaction with cardiovascular disease history and diabetes mellitus: The greecs observational study AU - Papataxiarchis, E. AU - Panagiotakos, D.B. AU - Notara, V. AU - Kouvari, M. AU - Kogias, Y. AU - Stravopodis, P. AU - Papanagnou, G. AU - Zombolos, S. AU - Mantas, Y. AU - Pitsavos, C. JO - Journal of aging and physical activity PY - 2016 VL - 24 TODO - 4 SP - 624-632 PB - Human Kinetics Publishers Inc SN - 1063-8652 TODO - 10.1123/japa.2015-0267 TODO - acute coronary syndrome; aged; clinical trial; diabetes mellitus; electrocardiography; exercise; female; Greece; human; incidence; lifestyle; male; middle aged; multicenter study; pathophysiology; physiology; prognosis; prospective study, Acute Coronary Syndrome; Aged; Diabetes Mellitus; Electrocardiography; Exercise; Female; Greece; Humans; Incidence; Life Style; Male; Middle Aged; Prognosis; Prospective Studies TODO - The association between physical activity, diabetes mellitus (DM), and long-term acute coronary syndrome (ACS) prognosis was evaluated. The GREECS study included 2,172 consecutive ACS patients from six Greek hospitals (2003-2004). In 2013-2014, a 10-year follow up was performed with 1,918 patients. Physical activity was categorized in never, rarely (monthly basis), 1-2 and ≥ 3 times/week. Multi-adjusted analysis revealed that 1-2 and ≥ 3 times/week vs. no physical activity had a protective effect on ACS incidence (OR ≥ 0.63 95% CI 0.38, 1.05) and (OR ≥ 0.63 95% CI 0.40, 0.99) respectively, only in patients without prior baseline CVD event. In a subgroup analysis, with DM as strata in these patients, engagement in physical activity (i.e., 1-2 times/week) had a signifcant protective effect among patients with diabetes (OR ≥ 0.51, 95% CI 0.27, 0.96, p ≥.037). These fndings revealed the benefcial role of exercise in secondary ACS prevention, even in DM patients. Public health-oriented policies should incorporate regular physical activity as a key protective factor in disease prognosis. © 2016 Human Kinetics, Inc. ER -