TY - JOUR
TI - Alterations in biomarkers of endothelial function following on-pump coronary artery revascularization
AU - Panagiotopoulos, I.
AU - Palatianos, G.
AU - Michalopoulos, A.
AU - Chatzigeorgiou, A.
AU - Prapas, S.
AU - Kamper, E.F.
JO - Journal of Clinical Laboratory Analysis
PY - 2010
VL - 24
TODO - 6
SP - 389-398
PB - John Wiley and Sons Inc
SN - 0887-8013, 1098-2825
TODO - 10.1002/jcla.20416
TODO - dipeptidyl carboxypeptidase;  endothelial leukocyte adhesion molecule 1;  PADGEM protein;  tetranectin;  von Willebrand factor;  ACE protein, human;  biological marker;  dipeptidyl carboxypeptidase;  lectin;  selectin;  tetranectin;  von Willebrand factor, adult;  aged;  article;  blood sampling;  cardioplegia;  clinical article;  controlled study;  coronary artery bypass graft;  coronary artery recanalization;  endothelium;  enzyme activity;  extracorporeal circulation;  female;  human;  male;  open heart surgery;  operation duration;  postoperative care;  postoperative period;  prospective study;  protein blood level;  blood;  cardiopulmonary bypass;  case control study;  coronary artery bypass graft;  middle aged;  pathophysiology;  systemic inflammatory response syndrome;  time;  vascular endothelium, Aged;  Biological Markers;  Cardiopulmonary Bypass;  Case-Control Studies;  Coronary Artery Bypass;  Endothelium, Vascular;  Female;  Humans;  Lectins, C-Type;  Male;  Middle Aged;  Peptidyl-Dipeptidase A;  Selectins;  Systemic Inflammatory Response Syndrome;  Time Factors;  von Willebrand Factor
TODO - Background: Cardiopulmonary bypass (CPB) has been associated with activation and injury of endothelial cells, probably responsible for the systemic inflammatory response syndrome (SIRS) taking place in these patients. Methods: We measured plasma concentrations of soluble P-selectin (sP-s), E-selectin (sE-s), tetranectin (TN), vonWillebrand factor (vWF) levels, and angiotensin-converting enzyme (ACE) activity in 31 adult patients undergoing elective coronary artery bypass grafting, just before and up to three days after surgery, and in 25 healthy volunteers. Results: Patients showed higher plasma sP-s and sE-s and ACE concentrations, just before surgery, but significantly lower TN levels, compared with controls. During the first three postoperative days (PD), the concentration of each of the molecules followed a different and independent pattern, although in the third PD, the levels of sP-s, sE-s and ACE were higher and those of vWF and TN lower, compared with the preoperative ones. However, patients had higher sP-s (P=0.06), sE-s (P=0.07), and vWF (P=0.005), but lower TN concentrations (P=0.02) on the third PD compared with controls. Conclusions: CPB is characterised by pronounced changes in plasma sP-s, sE-s, TN, vWF levels, and ACE activity, which are associated with significant alteration in the intra- and early postoperative endothelial function observed in open heart surgery. © 2010 Wiley-Liss, Inc.
ER -