TY - JOUR
TI - Administration of an intravenous fat emulsion enriched with medium-chain triglyceride/ω-3 fatty acids is beneficial towards anti-inflammatory related fatty acid profile in preterm neonates: A randomized, double-blind clinical trial
AU - Papandreou, P.
AU - Gioxari, A.
AU - Ntountaniotis, D.
AU - Korda, O.-N.
AU - Skouroliakou, M.
AU - Siahanidou, T.
JO - Nutrient Cycling in Agroecosystems
PY - 2020
VL - 12
TODO - 11
SP - 1-12
PB - MDPI AG
SN - 1385-1314
TODO - 10.3390/nu12113526
TODO - icosapentaenoic acid;  interleukin 6;  linoleic acid;  medium chain triacylglycerol;  oleic acid;  omega 3 fatty acid;  smoflipid;  icosapentaenoic acid;  interleukin 6;  linoleic acid;  lipid emulsion;  oleic acid;  omega 3 fatty acid;  omega 6 fatty acid;  soybean oil;  triacylglycerol, Article;  birth weight;  controlled study;  double blind procedure;  drug dose increase;  fatty acid analysis;  fatty acid blood level;  female;  gestational age;  human;  major clinical study;  male;  mass fragmentography;  newborn;  parallel design;  parenteral nutrition;  prematurity;  protein blood level;  randomized controlled trial;  sandwich ELISA;  blood;  chemistry;  growth, development and aging;  parenteral nutrition;  prematurity, Double-Blind Method;  Eicosapentaenoic Acid;  Fat Emulsions, Intravenous;  Fatty Acids, Omega-3;  Fatty Acids, Omega-6;  Female;  Humans;  Infant, Newborn;  Infant, Premature;  Interleukin-6;  Linoleic Acid;  Male;  Oleic Acid;  Parenteral Nutrition;  Soybean Oil;  Triglycerides
TODO - Intravenous administration of pure soybean oil emulsions high in linoleic acid may lead to inflammation and lipid peroxidation in preterm neonates. We aimed to investigate the effects of a medium-chain triglyceride (MCT)/ω-3 polyunsaturated fatty acid (PUFA)-enriched intravenous fat emulsion (IVFE) on plasma fatty acid (FA) profile and serum interleukin-6 (IL-6) in preterm neonates. In this double-blind randomized study, 92 preterm neonates (gestational age < 32 weeks, birth weight < 1500 g) were assigned to receive either MCT/ω-3 PUFA-enriched IVFE (Intervention Group) or soybean oil-based IVFE (Control Group). Levels of FAs were measured at baseline (day 0) and day 15 of parenteral nutrition with gas-chromatography mass-spectrometry. Serum IL-6 was measured with sandwich ELISA in 59 neonates. Plasma FAs changed significantly over time; the MCT/ω-3 PUFA-IVFE group showed higher ω-3 PUFAs (p = 0.031), eicosapentaenoic acid (p = 0.000), and oleic acid (p = 0.003), and lower ω-6/ω-3 PUFAs ratio (p = 0.001) and ω-6 PUFAs (p = 0.023) compared to control group. Linoleic acid was higher in the soybean oil (SO)-based IVFE arm compared to the MCT/ω-3 PUFAs-IVFE arm (p = 0.006). Both fat emulsion types decreased IL-6 compared to baseline, but changes were insignificant between groups. Administration of MCT/ω-3 PUFA-enriched IVFE in preterm neonates is beneficial in changing the FA profile consistent with attenuated inflammatory response. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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