TY - JOUR
TI - B12 as a treatment for peripheral neuropathic pain: A systematic review
AU - Julian, T.
AU - Syeed, R.
AU - Glascow, N.
AU - Angelopoulou, E.
AU - Zis, P.
JO - Nutrient Cycling in Agroecosystems
PY - 2020
VL - 12
TODO - 8
SP - 1-16
PB - MDPI AG
SN - 1385-1314
TODO - 10.3390/nu12082221
TODO - alpha tocopherol;  cobamamide;  colecalciferol;  cyanocobalamin;  folic acid;  gabapentin;  riboflavin;  cyanocobalamin, acupuncture;  analgesia;  daily life activity;  drug safety;  follow up;  Hamilton Depression Rating Scale;  hemodialysis;  human;  monotherapy;  myelination;  nerve block;  nerve regeneration;  pain intensity;  pain severity;  peripheral neuropathy;  quality of life;  questionnaire;  Review;  risk assessment;  systematic review;  thrombocyte rich plasma;  transcutaneous electrical nerve stimulation;  visual analog scale;  vitamin supplementation;  clinical trial (topic);  neuralgia;  observational study;  peripheral neuropathy;  treatment outcome, Clinical Trials as Topic;  Humans;  Neuralgia;  Observational Studies as Topic;  Peripheral Nervous System Diseases;  Treatment Outcome;  Vitamin B 12
TODO - Neuropathic pain describes a range of unpleasant sensations caused by a lesion or disease of the somatosensory nervous system. The sensations caused by neuropathic pain are debilitating and improved treatment regimens are sought in order to improve the quality of life of patients. One proposed treatment for neuropathic pain is vitamin B12, which is thought to alleviate pain by a number of mechanisms including promoting myelination, increasing nerve regeneration and decreasing ectopic nerve firing. In this paper, the evidence for B12 as a drug treatment for neuropathic pain is reviewed. Twenty four published articles were eligible for inclusion in this systematic review in which a range of treatment regimens were evaluated including both B12 monotherapy and B12 in combination with other vitamins or conventional treatments, such as gabapentinoids. Overall, this systematic review demonstrates that there is currently some evidence for the therapeutic effect of B12 in the treatment of post-herpetic neuralgia (level II evidence) and the treatment of painful peripheral neuropathy (level III evidence). © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
ER -