TY - JOUR
TI - Effect of traditional Greek Mediterranean meals on platelet aggregation in normal subjects and in patients with type 2 diabetes mellitus
AU - Antonopoulou, S.
AU - Fragopoulou, E.
AU - Karantonis, H.C.
AU - Mitsou, E.
AU - Sitara, M.
AU - Rementzis, J.
AU - Mourelatos, A.
AU - Ginis, A.
AU - Phenekos, C.
JO - Journal of Medicinal Food
PY - 2006
VL - 9
TODO - 3
SP - 356-362
PB - 
SN - 1096-620X
TODO - 10.1089/jmf.2006.9.356
TODO - adenosine diphosphate;  arachidonic acid;  thrombin;  thrombocyte activating factor;  adenosine diphosphate;  arachidonic acid;  thrombin;  thrombocyte activating factor, animal cell;  article;  atherosclerosis;  cardiovascular risk;  clinical article;  clinical trial;  controlled clinical trial;  controlled study;  female;  Greece;  human;  ischemic heart disease;  male;  Mediterranean diet;  non insulin dependent diabetes mellitus;  nonhuman;  priority journal;  randomized controlled trial;  thrombocyte aggregation;  thrombocyte function;  thrombocyte rich plasma;  adult;  aged;  blood;  diet therapy;  drug effect;  middle aged;  physiology, Subgroup A;  Subgroup B, Adenosine Diphosphate;  Adult;  Aged;  Arachidonic Acid;  Diabetes Mellitus, Type 2;  Diet, Mediterranean;  Female;  Greece;  Humans;  Male;  Middle Aged;  Platelet Activating Factor;  Platelet Aggregation;  Thrombin
TODO - Patients with type 2 diabetes mellitus have increased risk of cardiovascular disease. Epidemiological studies have shown a correlation between diet and incidence of coronary heart disease. The aim of the study is to determine the effect of a traditional Greek Mediterranean diet on platelet aggregation induced by ADP, arachidonic acid (AA), and especially platelet-activating factor (PAF) on patients with type 2 diabetes mellitus as well as on healthy volunteers. The patients were randomized into two subgroups, A and B. The lipid extracts from traditional Greek Mediterranean-type meals were tested in vitro for their ability to reduce PAF- or thrombin-induced platelet aggregation. The meals with the most potent anti-aggregating activity were chosen for the diet of both subgroup A and healthy subjects and consumed for a period of 28 days, whereas subgroup B kept to their regular diet that was followed before entering the study. Platelet-rich plasma was isolated before and after the diet, and the ability of platelets to aggregate under the aggregating factors was tested. One-month consumption of diet resulted in a significant reduction in PAF- and ADP-induced aggregation of platelets in both groups of healthy volunteers (PAF and ADP, P < .05) and subgroup A (PAF, P < .001; ADP, P < .05), whereas the AA-induced aggregation was not affected. No effect was observed in subgroup B, which followed the standard diet. Thus the consumption of a traditional Greek Mediterranean diet even for a short period can reduce platelet activity in patients suffering from type 2 diabetes mellitus and in healthy subjects. © Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition.
ER -