TY - JOUR TI - Chronic pain is a manifestation of the Ehlers-Danlos syndrome AU - Sacheti, A. AU - Szemere, J. AU - Bernstein, B. AU - Tafas, T. AU - Schechter, N. AU - Tsipouras, P. JO - Journal of Pain and Symptom Management PY - 1997 VL - 14 TODO - 2 SP - 88-93 PB - SN - 0885-3924 TODO - 10.1016/S0885-3924(97)00007-9 TODO - adult; article; autosomal recessive inheritance; capillary resistance; chronic pain; ehlers danlos syndrome; human; joint laxity; life expectancy; major clinical study; musculoskeletal system; symptomatology; wellbeing, Adaptation, Psychological; Adolescent; Adult; Aged; Child; Chronic Disease; Ehlers-Danlos Syndrome; Female; Humans; Interviews; Male; Middle Aged; Pain TODO - The Ehlers-Danlos syndrome (EDS) is a group of heritable systemic disorders of connective tissue manifesting joint hypermobility, skin extensibility, and tissue fragility. Although the presence of pain has been documented in the various types of the EDS, its natural history, distribution, and management have not been defined. We conducted a structured interview in 51 individuals affected with different types of EDS. Affected individuals reported chronic pain of early onset involving most frequently the shoulders, hands, and knees. Pain was generally refractory to a variety of pharmacologic and physical interventions. Chronic pain is a common manifestation of EDS. ER -