TY - JOUR
TI - Multiple primary squamous cell carcinomas of the lower lip and tongue arising in discoid lupus erythematosus: a case report
AU - Arvanitidou, I.-E.
AU - Nikitakis, N.G.
AU - Georgaki, M.
AU - Papadogeorgakis, N.
AU - Tzioufas, A.
AU - Sklavounou, A.
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
PY - 2018
VL - 125
TODO - 2
SP - e22-e30
PB - Mosby Year Book Inc
SN - 2212-4403
TODO - 10.1016/j.oooo.2017.08.012
TODO - adult;  case report;  discoid lupus erythematosus;  fatality;  female;  human;  lip tumor;  multiple cancer;  pathology;  squamous cell carcinoma;  tongue tumor, Adult;  Carcinoma, Squamous Cell;  Fatal Outcome;  Female;  Humans;  Lip Neoplasms;  Lupus Erythematosus, Discoid;  Neoplasms, Multiple Primary;  Tongue Neoplasms
TODO - Squamous cell carcinoma (SCC) developing in lesions of discoid lupus erythematosus (DLE) is rare, most frequently arising on sun-exposed skin and very rarely affecting the lips. A review of the English language literature revealed only 21 published cases of labial SCC in patients with DLE. Here, an unusual case of a patient with DLE who developed 3 primary SCCs of the oral and perioral region is presented. A 40-year-old female with a 24-year history of DLE with peri- and intraoral involvement initially developed SCC of the vermillion border of the right lower lip; the lesion was surgically removed and did not recur within 6 months. In spite of strong recommendation for regular follow-up, the patient failed to keep her appointments but returned 7 years later. No signs of recurrence of the original lower lip cancer were noticed, but a new SCC of the left lateral border of the tongue with cervical lymph node metastasis was diagnosed; despite aggressive combined treatment, locoregional recurrence and distant metastatic disease developed within a few months; in addition, a new primary SCC of the vermillion border of the left lower lip developed. This rare case and a thorough review of the pertinent literature underscore the possibility of development of even multiple intraoral and perioral SCCs in the context of longstanding DLE, which necessitates close long term follow-up for early diagnosis and management. © 2017 Elsevier Inc.
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