TY - JOUR
TI - Impairment of learning and memory in TAG-1 deficient mice associated with shorter CNS internodes and disrupted juxtaparanodes
AU - Savvaki, M.
AU - Panagiotaropoulos, T.
AU - Stamatakis, A.
AU - Sargiannidou, I.
AU - Karatzioula, P.
AU - Watanabe, K.
AU - Stylianopoulou, F.
AU - Karagogeos, D.
AU - Kleopa, K.A.
JO - MOLECULAR AND CELLULAR NEUROSCIENCE
PY - 2008
VL - 39
TODO - 3
SP - 478-490
PB - 
SN - 1044-7431
TODO - 10.1016/j.mcn.2008.07.025
TODO - nerve cell adhesion molecule;  transient axonal glycoprotein 1;  unclassified drug, animal experiment;  animal model;  article;  central nervous system;  cerebellum;  cognitive defect;  controlled study;  entorhinal cortex;  experimental mouse;  human;  internode;  learning disorder;  memory disorder;  motor activity;  mouse;  nociceptive stimulation;  nonhuman;  olfactory bulb;  priority journal;  recognition;  white matter, Animals;  Axons;  Behavior, Animal;  Cell Adhesion Molecules, Neuronal;  Central Nervous System;  Humans;  Kv1.1 Potassium Channel;  Kv1.2 Potassium Channel;  Learning Disorders;  Male;  Memory Disorders;  Mice;  Mice, Knockout;  Myelin Sheath;  Neuropsychological Tests, Animalia;  Mus
TODO - The cell adhesion molecule TAG-1 is expressed by neurons and glial cells and plays a role in axon outgrowth, migration and fasciculation during development. TAG-1 is also required for the clustering of Kv1.1/1.2 potassium channels and Caspr2 at the juxtaparanodes of myelinated fibers. Behavioral examination of TAG-1 deficient mice (Tag-1-/-) showed cognitive impairments in the Morris water maze and novel object recognition tests, reduced spontaneous motor activity, abnormal gait coordination and increased response latency to noxious stimulation. Investigation at the molecular level revealed impaired juxtaparanodal clustering of Caspr2 and Kv1.1/1.2 in the hippocampus, entorhinal cortex, cerebellum and olfactory bulb, with diffusion into the internode. Caspr2 and Kv1.1 levels were reduced in the cerebellum and olfactory bulb. Moreover, Tag-1-/- mice had shorter internodes in the cerebral and cerebellar white matter. The detected molecular alterations may account for the behavioural deficits and hyperexcitability in these animals. © 2008 Elsevier Inc. All rights reserved.
ER -