TY - JOUR
TI - The effects of rivastigmine plus selegiline on brain acetylcholinesterase, (Na+, K+)-, Mg2+- ATPase activities, antioxidant status, and learning performance of aged rats
AU - Carageorgiou, H.
AU - Sideris, A.C.
AU - Messari, I.
AU - Liakou, C.I.
AU - Tsakiris, S.
JO - Neuropsychiatric Disease and Treatment
PY - 2008
VL - 4
TODO - 4
SP - 687-699
PB - Dove Medical Press Ltd
SN - 1176-6328, 1178-2021
TODO - 10.2147/ndt.s3272
TODO - acetylcholinesterase;  adenosine triphosphatase (magnesium);  adenosine triphosphatase (potassium sodium);  free radical;  norselegiline;  rivastigmine;  sodium chloride, age distribution;  aged;  animal behavior;  animal experiment;  animal tissue;  antioxidant activity;  article;  biochemistry;  brain function;  chronic drug administration;  cognition;  combination chemotherapy;  controlled study;  drug potentiation;  enzyme activation;  enzyme activity;  enzyme inhibition;  learning;  male;  monotherapy;  nonhuman;  passive avoidance;  rat;  recognition;  statistical significance
TODO - We investigated the effects of rivastigmine (a cholinesterase inhibitor) and selegiline ((-)deprenyl, an irreversible inhibitor of monoamineoxidase-B), alone and in combination, on brain acetylcholinesterase (AChE), (Na+, K+)-, Mg2+-ATPase activities, total antioxidant status (TAS), and learning performance, after long-term drug administration in aged male rats. The possible relationship between the biochemical and behavioral parameters was evaluated. Methods: Aged rats were treated (for 36 days) with rivastigmine (0.3 mg/ kg rat/day ip), selegiline (0.25 mg/kg rat/day im), rivastigmine plus selegiline in the same doses and way of administration as separately. Aged and adult control groups received NaCl 0.9% 0.5 ml ip. Results: TAS was lower in aged than in adult rats, rivastigmine alone does not affect TAS, decreases AChE activity, increases (Na+, K+)-ATPase and Mg2+-ATPase activity of aged rat brain and improves cognitive performance. Selegiline alone decreases free radical production and increases AChE activity and (Na+, K+)-ATPase activity, improving cognitive performance as well. In the combination: rivastigmine seems to cancel selegiline action on TAS and AChE activity, while it has additive effect on (Na+, K+)-ATPase activity. In the case of Mg2+-ATPase selegiline appears to attenuate rivastigmine activity. No statistically significant difference was observed in the cognitive performance. Conclusion: Reduced TAS, AChE activity and learning performance was observed in old rats. Both rivastigmine and selesiline alone improved performance, although they influenced the biochemical parameters in a different way. The combination of the two drugs did not affect learning performance. © 2008 Carageorgiou et al, publisher and licensee Dove Medical Press Ltd.
ER -