TY - JOUR
TI - Staging of neurofibrillary pathology in Alzheimer's disease: A study of the BrainNet Europe consortium
AU - Alafuzoff, I.
AU - Arzberger, T.
AU - Al-Sarraj, S.
AU - Bodi, I.
AU - Bogdanovic, N.
AU - Braak, H.
AU - Bugiani, O.
AU - Del-Tredici, K.
AU - Ferrer, I.
AU - Gelpi, E.
AU - Giaccone, G.
AU - Graeber, M.B.
AU - Ince, P.
AU - Kamphorst, W.
AU - King, A.
AU - Korkolopoulou, P.
AU - Kovács, G.G.
AU - Larionov, S.
AU - Meyronet, D.
AU - Monoranu, C.
AU - Parchi, P.
AU - Patsouris, E.
AU - Roggendorf, W.
AU - Seilhean, D.
AU - Tagliavini, F.
AU - Stadelmann, C.
AU - Streichenberger, N.
AU - Thal, D.R.
AU - Wharton, S.B.
AU - Kretzschmar, H.
JO - Brain Pathology
PY - 2008
VL - 18
TODO - 4
SP - 484-496
PB - Wiley-Blackwell Publishing Ltd
SN - 1015-6305, 1750-3639
TODO - 10.1111/j.1750-3639.2008.00147.x
TODO - amyloid beta protein;  tau protein, adult;  aged;  Alzheimer disease;  article;  brain tissue;  clinical article;  clinical assessment;  clinical laboratory;  dementia;  disease course;  Europe;  female;  human;  human tissue;  immunohistochemistry;  male;  neurofibrillary tangle;  neurologic disease;  neuropathology;  pathologist;  protein phosphorylation;  senile plaque
TODO - It has been recognized that molecular classifications will form the basis for neuropathological diagnostic work in the future. Consequently, in order to reach a diagnosis of Alzheimer's disease (AD), the presence of hyperphosphorylated tau (HP-tau) and β-amyloid protein in brain tissue must be unequivocal. In addition, the stepwise progression of pathology needs to be assessed. This paper deals exclusively with the regional assessment of AD-related HP-tau pathology. The objective was to provide straightforward instructions to aid in the assessment of AD-related immunohistochemically (IHC) detected HP-tau pathology and to test the concordance of assessments made by 25 independent evaluators. The assessment of progression in 7-μm-thick sections was based on assessment of IHC labeled HP-tau immunoreactive neuropil threads (NTs). Our results indicate that good agreement can be reached when the lesions are substantial, i.e., the lesions have reached isocortical structures (stage V-VI absolute agreement 91%), whereas when only mild subtle lesions were present the agreement was poorer (I-II absolute agreement 50%). Thus, in a research setting when the extent of lesions is mild, it is strongly recommended that the assessment of lesions should be carried out by at least two independent observers. © 2008 The Authors.
ER -