TY - JOUR
TI - An experimental antidepressant increases rem sleep
AU - Soldatos, C.R.
AU - Stefanis, C.N.
AU - Bergiannaki, J.D.
AU - Christodoulou, C.
AU - Botsis, A.
AU - Sakkas, P.N.
JO - Progress in Neuropsychopharmacology and Biological Psychiatry
PY - 1988
VL - 12
TODO - 6
SP - 899-907
PB - 
SN - null
TODO - 10.1016/0278-5846(88)90086-3
TODO - 4 aminobutyric acid;  s 3344;  thyrotropin;  tricyclic antidepressant agent, adult;  clinical article;  electroencephalography;  female;  human;  male;  oral drug administration;  rem sleep, Antidepressive Agents;  Antidepressive Agents, Tricyclic;  Comparative Study;  Depressive Disorder;  Dexamethasone;  Human;  Hydrocortisone;  Reference Values;  Sleep Stages;  Sleep, REM;  Support, Non-U.S. Gov't;  Wakefulness
TODO - 1. 1. An experimental antidepressant was studied through sleep laboratory recordings, psychoendocrinological tests and clinical measurements in terms of its efficacy, side effects and effects on sleep. 2. 2. The design included a four-week drug administration period, proceeded and followed by a one week placebo period. 3. 3. In the presence of antidepressant efficacy, the drug did not disturb sleep induction and maintainance. 4. 4. The only effect on sleep stages was an increase of REM sleep during the short-term drug administration period which is contrary to the REM supressant effect of most antidepressants. 5. 5. This finding suggests that REM supression and antidepressant efficacy are not necessarily related. 6. 6. Further, given that the only known action of the drug is its inhibitory effect on GABA-ergic transmission, one can speculate that GABA mechanisms may be involved in REM sleep modulation. © 1988.
ER -