TY - JOUR
TI - The relation of integrated psychological therapy to resting state functional brain connectivity networks in patients with schizophrenia
AU - Gallos, I.K.
AU - Mantonakis, L.
AU - Spilioti, E.
AU - Kattoulas, E.
AU - Savvidou, E.
AU - Anyfandi, E.
AU - Karavasilis, E.
AU - Kelekis, N.
AU - Smyrnis, N.
AU - Siettos, C.I.
JO - Psychiatry Research
PY - 2021
VL - 306
TODO - null
SP - null
PB - Elsevier Ireland Ltd
SN - 0165-1781
TODO - 10.1016/j.psychres.2021.114270
TODO - biological marker, adult;  Article;  clinical article;  clinical feature;  cognitive behavioral therapy;  cognitive remediation therapy;  controlled study;  default mode network;  disease duration;  executive function;  female;  follow up;  frontoparietal network;  functional connectivity;  functional magnetic resonance imaging;  human;  learning algorithm;  male;  perception;  resting state network;  schizophrenia;  social status;  therapy effect
TODO - Functional brain dysconnectivity measured with resting state functional magnetic resonance imaging (rsfMRI) has been linked to cognitive impairment in schizophrenia. This study investigated the effects on functional brain connectivity of Integrated Psychological Therapy (IPT), a cognitive behavioral oriented group intervention program, in 31 patients with schizophrenia. Patients received IPT or an equal intensity non-specific psychological treatment in a non-randomized design. Evidence of improvement in executive and social functions, psychopathology and overall level of functioning was observed after treatment completion at six months only in the IPT treatment group and was partially sustained at one-year follow up. Independent Component Analysis and Isometric Mapping (ISOMAP), a non-linear manifold learning algorithm, were used to construct functional connectivity networks from the rsfMRI data. Functional brain dysconnectivity was observed in patients compared to a group of 17 healthy controls, both globally and specifically including the default mode (DMN) and frontoparietal network (FPN). DMN and FPN connectivity were reversed towards healthy control patterns only in the IPT treatment group and these effects were sustained at follow up for DMN but not FPN. These data suggest the use of rsfMRI as a biomarker for accessing and monitoring the therapeutic effects of cognitive remediation therapy in schizophrenia. © 2021 Elsevier B.V.
ER -