TY - JOUR
TI - COVID-19 and ischemic stroke
AU - Sagris, D.
AU - Papanikolaou, A.
AU - Kvernland, A.
AU - Korompoki, E.
AU - Frontera, J.A.
AU - Troxel, A.B.
AU - Gavriatopoulou, M.
AU - Milionis, H.
AU - Lip, G.Y.H.
AU - Michel, P.
AU - Yaghi, S.
AU - Ntaios, G.
JO - European Journal of Paediatric Neurology
PY - 2021
VL - 28
TODO - 11
SP - 3826-3836
PB - John Wiley and Sons Inc
SN - 1090-3798
TODO - 10.1111/ene.15008
TODO - coronavirus disease 2019;  global health;  heart disease;  human;  incidence;  intensive care unit;  ischemic stroke;  Medline;  pathophysiology;  practice guideline;  prevalence;  Review;  Scopus;  signal transduction;  thrombosis;  brain ischemia;  cerebrovascular accident;  complication;  pandemic, Brain Ischemia;  COVID-19;  Humans;  Ischemic Stroke;  Pandemics;  SARS-CoV-2;  Stroke
TODO - Since the onset of the COVID-19 pandemic, a substantial proportion of COVID-19 patients had documented thrombotic complications and ischemic stroke. Several mechanisms related to immune-mediated thrombosis, the renin angiotensin system and the effect of SARS-CoV-2 in cardiac and brain tissue may contribute to the pathogenesis of ischemic stroke in patients with COVID-19. Simultaneously, significant strains on global healthcare delivery, including ischemic stroke management, have made treatment of stroke in the setting of COVID-19 particularly challenging. In this review, we summarize the current knowledge on epidemiology, clinical manifestation, and pathophysiology of ischemic stroke in patients with COVID-19 to bridge the gap from bench to bedside and clinical practice during the most challenging global health crisis of the last decades. © 2021 European Academy of Neurology
ER -