TY - JOUR
TI - Early auditory-evoked potentials in body dysmorphic disorder: An ERP/sLORETA study
AU - Giannopoulos, A.E.
AU - Zioga, I.
AU - Papageorgiou, P.C.
AU - Kapsali, F.
AU - Spantideas, S.T.
AU - Kapsalis, N.C.
AU - Capsalis, C.N.
AU - Kontoangelos, K.
AU - Papageorgiou, C.C.
JO - Psychiatry Research
PY - 2014
VL - 299
TODO - null
SP - null
PB - Elsevier Ireland Ltd
SN - 0165-1781
TODO - 10.1016/j.psychres.2021.113865
TODO - adult;  Article;  auditory evoked potential;  auditory network;  body dysmorphic disorder;  brain electrophysiology;  clinical article;  controlled study;  disease severity assessment;  electroencephalogram;  event related potential;  female;  human;  male;  nerve potential;  prepulse facilitation;  prepulse inhibition;  priority journal;  sensory gating;  stimulus response;  auditory evoked potential;  auditory stimulation;  body dysmorphic disorder;  evoked response;  startle reflex, Acoustic Stimulation;  Adult;  Body Dysmorphic Disorders;  Evoked Potentials;  Evoked Potentials, Auditory;  Humans;  Reflex, Startle
TODO - Body dysmorphic disorder (BDD) is characterized by excessive preoccupation with imagined or slight physical defects in appearance. BDD is associated with cognitive impairments (attention, visual processing). Our study aims to evaluate the early neural responses (N100, P200) to prepulse inhibition (PPI) and prepulse facilitation (PPF), to investigate attentional processing of BDD in the auditory domain. Fifty-five adults took part: 30 BDD patients and 25 healthy controls. We compared their brain responses to PPI and PPF by analyzing global field power (GFP), event-related potentials (ERPs) and their respective sources. BDD exhibited reduced N100 amplitudes compared to healthy controls in response to the startle tone elicited by both PPI and PPF, potentially suggesting impaired allocation of attention. Interestingly, the lower the GFP at the N100, the higher the BDD severity. Source reconstruction analysis showed reduced activation for BDD during the N100 time window in PPI. Scalp responses and source activations in PPI were decreased overall compared to PPF, confirming the gating effect of PPI. We provided evidence that the N100 may serve as an electrophysiological marker of BDD, predicting its severity. Our study demonstrated the potential of using ERPs combined with behavioural PPI and PPF protocols to advance our understanding of BDD pathophysiology. © 2021 Elsevier B.V.
ER -