TY - JOUR
TI - Xanthotoxin affects depression-related behavior and neurotransmitters content in a sex-dependent manner in mice
AU - Kowalczyk, J.
AU - Nakos-Bimpos, M.
AU - Polissidis, A.
AU - Dalla, C.
AU - Kokras, N.
AU - Skalicka-Wozniak, K.
AU - Budzynska, B.
JO - BEHAVIOURAL BRAIN RESEARCH
PY - 2021
VL - 399
TODO - null
SP - null
PB - Elsevier B.V.
SN - 0166-4328
TODO - 10.1016/j.bbr.2020.112985
TODO - imipramine;  methoxsalen;  noradrenalin;  serotonin;  antidepressant agent;  methoxsalen;  noradrenalin;  plant medicinal product;  serotonin, animal experiment;  animal model;  animal tissue;  antidepressant activity;  Article;  behavior assessment;  concentration response;  controlled study;  depression;  dose response;  female;  forced swim test;  high performance liquid chromatography;  hippocampus;  immobility time;  liquid chromatography;  locomotion;  male;  mouse;  neurotransmitter release;  nonhuman;  prefrontal cortex;  priority journal;  sex difference;  animal;  animal behavior;  depression;  drug effect;  metabolism;  sex factor;  sexual characteristics, Animals;  Antidepressive Agents;  Behavior, Animal;  Depression;  Female;  Hippocampus;  Male;  Methoxsalen;  Mice;  Norepinephrine;  Plant Preparations;  Prefrontal Cortex;  Serotonin;  Sex Characteristics;  Sex Factors
TODO - The present study aimed to evaluate xanthotoxin's influence on male and female Swiss mice's depression-like behaviors and investigate the potential mechanism of this effect. Naturally derived furanocoumarin (the Apiaceae family), xanthotoxin, administered acutely (12.5 mg/kg), diminished the immobility level in the forced swim test only in males. The immobility level was lower in females than males, which may be associated with a higher serotonin level in the female prefrontal cortex. A dose-dependent increase of serotonin and noradrenaline was reported in the reverse-phase ion-pair liquid chromatography in the female prefrontal cortex but not in the hippocampus. We suggest that xanthotoxin may exert antidepressant properties and affect males and females differently. The increasing level of serotonin in the male and female prefrontal cortex may underlie this effect. © 2020 Elsevier B.V.
ER -