TY - JOUR
TI - Cerebro-cerebellar white matter connectivity in bipolar disorder and associated polarity subphenotypes
AU - Argyropoulos, G.D.
AU - Christidi, F.
AU - Karavasilis, E.
AU - Velonakis, G.
AU - Antoniou, A.
AU - Bede, P.
AU - Seimenis, I.
AU - Kelekis, N.
AU - Douzenis, A.
AU - Papakonstantinou, O.
AU - Efstathopoulos, E.
AU - Ferentinos, P.
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
PY - 2021
VL - 104
TODO - null
SP - null
PB - ELSEVIER SCIENCE INC 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN - 0278-5846
TODO - 10.1016/j.pnpbp.2020.110034
TODO - anticonvulsive agent;  antidepressant agent;  lithium salt;  neuroleptic agent, adult;  Article;  bipolar depression;  bipolar disorder;  bipolar mania;  cerebrocerebellar tract;  cerebrocerebellar white matter connectivity;  clinical article;  cohort analysis;  controlled study;  diffusion tensor imaging;  female;  fractional anisotropy;  frontopontocerebellar tract;  functional connectivity;  gray matter;  human;  left hemisphere;  male;  middle aged;  nerve tract;  occipitopontocerebellar tract;  parietopontocerebellar tract;  phenotype;  right hemisphere;  bipolar disorder;  cerebellum;  cross-sectional study;  diagnostic imaging;  frontal lobe;  nerve cell network;  procedures;  psychology, Adult;  Bipolar Disorder;  Cerebellum;  Cerebrum;  Cross-Sectional Studies;  Diffusion Tensor Imaging;  Female;  Frontal Lobe;  Humans;  Male;  Middle Aged;  Nerve Net
TODO - Background: The cerebellum has a crucial role in mood regulation. While cerebellar grey matter (GM) alterations have been previously reported in bipolar disorder (BD), cerebro-cerebellar white matter (WM) connectivity alterations and cerebellar GM profiles have not been characterised in the context of predominant polarity (PP) and onset polarity (OP) subphenotypes of BD patients which is the aim of the present study. Methods: Forty-two euthymic BD patients stratified for PP and OP and 42 healthy controls (HC) were included in this quantitative neuroimaging study to evaluate cerebellar GM patterns and cerebro-cerebellar WM connections. Diffusion tensor tractography was used to characterise afferent and efferent cerebro-cerebellar tract integrity. False discovery rate corrections were applied in post-hoc comparisons. Results: BD patients exhibited higher fractional anisotropy (FA) in fronto-ponto-cerebellar tracts bilaterally compared to HC. Subphenotype-specific FA profiles were identified within the BD cohort. Regarding PP subgroups, we found FA changes in a) left contralateral fronto-ponto-cerebellar tract (depressive-PP > HC) and b) contralateral/ipsilateral fronto-ponto-cerebellar tracts bilaterally (manic-PP > HC). Regarding OP subgroups, we observed FA changes in a) left/right contralateral fronto-ponto-cerebellar tracts (depressive-OP > HC) and b) all fronto-ponto-cerebellar, most parieto-ponto-cerebellar and right contralateral occipito-ponto-cerebellar tracts (manic-OP>HC). In general, greater and more widespread cerebro-cerebellar changes were observed in manic-OP patients than in depressive-OP patients compared to HC. Manic-OP showed higher FA compared to depressive-OP patients in several afferent WM tracts. No GM differences were identified between BD and HC and across BD subgroups. Conclusions: Our findings highlight fronto-ponto-cerebellar connectivity alterations in euthymic BD. Polarity-related subphenotypes have distinctive cerebro-cerebellar WM signatures with potential clinical and pathobiological implications. © 2020 Elsevier Inc.
ER -