TY - JOUR TI - An updated brief overview on post-traumatic headache and a systematic review of the non-pharmacological interventions for its management AU - Argyriou, A.A. AU - Mitsikostas, D.-D. AU - Mantovani, E. AU - Litsardopoulos, P. AU - Panagiotopoulos, V. AU - Tamburin, S. JO - Expert Review of Neurotherapeutics PY - 2021 VL - 21 TODO - 4 SP - 475-490 PB - Taylor and Francis Ltd. SN - 1473-7175, 1744-8360 TODO - 10.1080/14737175.2021.1900734 TODO - placebo, acupuncture; adult; Beck Depression Inventory; behavior therapy; binocular vision dysfunction questionnaire; brain depth stimulation; Brief Pain Inventory; brief pain inventory headache; british columbia post concussion symptom inventory; chronic pain grade; clinical feature; clinician administered ptsd scale; cognitive behavioral exercise approach; cognitive behavioral therapy; cognitive defect; comorbidity; conner continuous performance test; dizziness handicap inventory; dorsolateral prefrontal cortex; Dynamic Gait Index; epidemiological data; evidence based practice; female; functional near-infrared spectroscopy; Generalized Anxiety Disorder-7; Hamilton Depression Rating Scale; headache; headache and facial pain; headache triggers sensitivity and avoidance questionnaire; Hopkins verbal learning test; human; kinesiotherapy; learning to cope with trigger; Major Depression Inventory; male; managed care; medical outcomes study sleep scale; mental disease; migraine; migraine disability assessment scale; mississippi scale; molecular pathology; multidimensional fatigue inventory; neck pain; needling therapy; nerve stimulation; neuromodulation; pain assessment; pathophysiology; Patient Health Questionnaire 9; physiotherapy; Pittsburgh Sleep Quality Index; posttraumatic headache; posttraumatic stress disorder; preemptive therapy; Preferred Reporting Items for Systematic Reviews and Meta-Analyses; psychological aspect; randomized controlled trial (topic); rehabilitation care; Review; Satisfaction with Life Scale; self efficacy for symptom management scale; Short Form 36; spreading cortical depression; Stroop test; symptom; Symptom Checklist 90; systematic review; tension headache; traumatic brain injury; Wechsler adult intelligence scale; whiplash injury; cognitive behavioral therapy; migraine; posttraumatic headache; traumatic brain injury, Brain Injuries, Traumatic; Cognitive Behavioral Therapy; Headache; Humans; Migraine Disorders; Post-Traumatic Headache TODO - Introduction: Post-traumatic headache (PTH), a common type of headache secondary to traumatic brain injury (TBI) or whiplash, carries a relevant burden on patients. PTH is still an undertreated condition because of limited pharmacological treatment options. Therefore, multimodal non-pharmacologic approaches, which account for comorbidities and biopsychosocial factors, are often used in PTH patients. Areas covered: After providing a brief overview of PTH, a systematic review was conducted, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations on recently published (2015–2020) papers on non-pharmacological interventions for PTH. We also collected data on ongoing trials on this topic. Studies and results are reviewed and discussed. Expert opinion: PTH is one of the most common complications of TBI and accounts for almost 4% of symptomatic headache disorders. The most common clinical presentations of PTH are migraine-like or tension type (TTH)-like headache, neck pain, cognitive complaints, and psychological/psychiatric symptoms. Growing evidence suggests that combined pharmacological and non-pharmacological interventions, encompassing noninvasive neuromodulation, physical therapy, cognitive-behavioral treatment, and education, may be the best approaches for PTH and related comorbidities. Acute/preemptive pharmacological treatments for PTH include drugs used for migraine and TTH. When PTH management is multidisciplinary, the patient benefits most. © 2021 Informa UK Limited, trading as Taylor & Francis Group. ER -