TY - JOUR
TI - Paraneoplastic cerebellar degeneration in a patient with breast cancer associated with carbonic anhydrase–related protein VIII autoantibodies
AU - Prevezianou, A.
AU - Tzartos, J.S.
AU - Dagklis, I.E.
AU - Bentenidi, E.
AU - Angelopoulos, P.
AU - Bostantjopoulou, S.
JO - Journal of Neuroimmunology
PY - 2020
VL - 344
TODO - null
SP - null
PB - Elsevier B.V.
SN - 0165-5728
TODO - 10.1016/j.jneuroim.2020.577242
TODO - autoantibody;  carbonate dehydratase;  carbonic anhydrase related protein VIII;  immunoglobulin;  oligoclonal band;  paclitaxel;  unclassified drug;  autoantibody;  CA8 protein, human;  protein binding;  tumor marker, aged;  antibody titer;  Article;  Babinski reflex;  bradyphrenia;  breast cancer;  cancer adjuvant therapy;  cancer surgery;  case report;  cerebellum disease;  cerebrospinal fluid analysis;  clinical article;  cytoplasm;  diplopia;  dizziness;  drug withdrawal;  dysarthria;  dyskinesia;  dysmetria;  female;  follow up;  gait disorder;  human;  immobility;  leukoencephalopathy;  leukopenia;  multiple cycle treatment;  neurologic examination;  nuclear magnetic resonance imaging;  paraneoplastic neuropathy;  priority journal;  protein cerebrospinal fluid level;  Purkinje cell;  tremor;  animal;  breast tumor;  cerebellum;  complication;  Haplorhini;  HEK293 cell line;  metabolism;  paraneoplastic neuropathy;  pathology;  physiology, Aged;  Animals;  Autoantibodies;  Biomarkers, Tumor;  Breast Neoplasms;  Cerebellum;  Female;  Haplorhini;  HEK293 Cells;  Humans;  Paraneoplastic Cerebellar Degeneration;  Protein Binding
TODO - Paraneoplastic cerebellar degeneration is a neurological syndrome resulting from immune-mediated dysfunction of Purkinje cells and commonly is associated with a tumor. In most cases, well-characterized onconeural antibodies are detected, such as anti-Yo and anti-Ri antibodies. Carbonic anhydrase-related protein VIII (CARP VIII) antibodies associated with paraneoplastic cerebellar degeneration have been previously described in only two cases. Herein, we present a 75-year-old female who developed progressive cerebellar ataxia. Anti-CARP VIII autoantibodies were found at high titres and screening for underlying malignancies revealed a breast cancer. Intravenous immunoglobulin was administered with poor results. Our report further confirms the role of CARP VIII antibodies in cerebellar degeneration. © 2020 Elsevier B.V.
ER -