TY - JOUR
TI - Alcohol Consumption and Risk of Parkinson's Disease: Data From a Large Prospective European Cohort
AU - Peters, S.
AU - Gallo, V.
AU - Vineis, P.
AU - Middleton, L.T.
AU - Forsgren, L.
AU - Sacerdote, C.
AU - Sieri, S.
AU - Kyrozis, A.
AU - Chirlaque, M.-D.
AU - Zamora-Ros, R.
AU - Hansson, O.
AU - Petersson, J.
AU - Katzke, V.
AU - Kühn, T.
AU - Mokoroa, O.
AU - Masala, G.
AU - Ardanaz, E.
AU - Panico, S.
AU - Bergmann, M.M.
AU - Key, T.J.
AU - Weiderpass, E.
AU - Ferrari, P.
AU - Vermeulen, R.
JO - Movement Disorders
PY - 2020
VL - 35
TODO - 7
SP - 1258-1263
PB - John Wiley and Sons Inc
SN - 0885-3185, 1531-8257
TODO - 10.1002/mds.28039
TODO - adult;  aged;  alcohol consumption;  Article;  cohort analysis;  demography;  Europe;  female;  human;  lifespan;  major clinical study;  male;  Parkinson disease;  priority journal;  prospective study;  risk;  adverse event;  coffee;  drinking behavior;  Parkinson disease;  risk factor, Alcohol Drinking;  Coffee;  Cohort Studies;  Humans;  Male;  Parkinson Disease;  Prospective Studies;  Risk Factors
TODO - Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective: To assess the associations between alcohol consumption and PD risk. Methods: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5–29.9 g/day) were at ~50% higher risk compared with light consumption (0.1–4.9 g/day), but no linear exposure–response trend was observed. Analyses by beverage type also revealed no associations with PD. Conclusion: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
ER -