TY - JOUR
TI - Colchicine for stroke prevention in patients with coronary artery disease: a systematic review and meta-analysis
AU - Katsanos, A.H.
AU - Palaiodimou, L.
AU - Price, C.
AU - Giannopoulos, S.
AU - Lemmens, R.
AU - Kosmidou, M.
AU - Georgakis, M.K.
AU - Weimar, C.
AU - Kelly, P.J.
AU - Tsivgoulis, G.
JO - European Journal of Paediatric Neurology
PY - 2020
VL - 27
TODO - 6
SP - 1035-1038
PB - Wiley-Blackwell Publishing Ltd
SN - 1090-3798
TODO - 10.1111/ene.14198
TODO - colchicine, Article;  cerebrovascular accident;  coronary artery disease;  follow up;  human;  incidence;  low drug dose;  meta analysis;  priority journal;  randomized controlled trial (topic);  risk reduction;  systematic review;  therapy effect
TODO - Background and purpose: Although clinical trials suggest that colchicine may reduce the risk of vascular events in patients with a history of coronary artery disease, its effect on the prevention of cerebrovascular events still remains unclear. Methods: A systematic review and meta-analysis was performed of all available randomized controlled trials (RCTs) reporting on incident strokes during the follow-up of patients with a history of cardiovascular disease randomized to colchicine treatment or control (placebo or usual care). Results: Four RCTs were identified, including a total of 5553 patients (mean age 61 years, 81% males), with a follow-up ranging from 1 to 36 months. Colchicine treatment was associated with a significantly lower risk of incident stroke during follow-up compared to control (risk ratio 0.31, 95% confidence interval 0.13–0.71), without heterogeneity across included studies (I2 = 0%). Based on the pooled incident stroke rate of control groups (0.9%) in the included RCTs, it was estimated that administration of low-dose colchicine to 161 patients with coronary artery disease would prevent one stroke during a follow-up of 23 months. Conclusion: Colchicine treatment decreases stroke risk in patients with a history of coronary artery disease. The effect of colchicine in secondary stroke prevention is currently being evaluated in an ongoing RCT. © 2020 European Academy of Neurology
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