TY - JOUR
TI - Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia
AU - Slot, R.E.R.
AU - Sikkes, S.A.M.
AU - Berkhof, J.
AU - Brodaty, H.
AU - Buckley, R.
AU - Cavedo, E.
AU - Dardiotis, E.
AU - Guillo-Benarous, F.
AU - Hampel, H.
AU - Kochan, N.A.
AU - Lista, S.
AU - Luck, T.
AU - Maruff, P.
AU - Molinuevo, J.L.
AU - Kornhuber, J.
AU - Reisberg, B.
AU - Riedel-Heller, S.G.
AU - Risacher, S.L.
AU - Roehr, S.
AU - Sachdev, P.S.
AU - Scarmeas, N.
AU - Scheltens, P.
AU - Shulman, M.B.
AU - Saykin, A.J.
AU - Verfaillie, S.C.J.
AU - Visser, P.J.
AU - Vos, S.J.B.
AU - Wagner, M.
AU - Wolfsgruber, S.
AU - Jessen, F.
AU - Boada, M.
AU - de Deyn, P.P.
AU - Jones, R.
AU - Frisoni, G.
AU - Spiru, L.
AU - Nobili, F.
AU - Freund-Levi, Y.
AU - Soininen, H.
AU - Verhey, F.
AU - Wallin, Å.K.
AU - Touchon, J.
AU - Rikkert, M.O.
AU - Rigaud, A.-S.
AU - Bullock, R.
AU - Tsolaki, M.
AU - Vellas, B.
AU - Wilcock, G.
AU - Froelich, L.
AU - Bakardjian, H.
AU - Benali, H.
AU - Bertin, H.
AU - Bonheur, J.
AU - Boukadida, L.
AU - Boukerrou, N.
AU - Chiesa, P.
AU - Colliot, O.
AU - Dubois, B.
AU - Dubois, M.
AU - Epelbaum, S.
AU - Gagliardi, G.
AU - Genthon, R.
AU - Habert, M.-O.
AU - Houot, M.
AU - Kas, A.
AU - Lamari, F.
AU - Levy, M.
AU - Metzinger, C.
AU - Mochel, F.
AU - Nyasse, F.
AU - Poisson, C.
AU - Potier, M.-C.
AU - Revillon, M.
AU - Santos, A.
AU - Andrade, K.S.
AU - Sole, M.
AU - Surtee, M.
AU - Thiebaud de Schotten, M.
AU - Vergallo, A.
AU - Younsi, N.
AU - van der Flier, W.M.
AU - Alzheimer's Disease Neuroimaging Initiative
AU - DESCRIPA working group
AU - INSIGHT-preAD study group
AU - SCD-I working group
JO - American Journal of Alzheimer's Disease and other Dementias
PY - 2019
VL - 15
TODO - 3
SP - 465-476
PB - ELSEVIER SCIENCE INC 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN - 1533-3175
TODO - 10.1016/j.jalz.2018.10.003
TODO - apolipoprotein E4, adult;  aged;  Alzheimer disease;  Article;  cognition assessment;  cognitive defect;  cohort analysis;  controlled study;  dementia;  disease exacerbation;  female;  frontotemporal dementia;  human;  incidence;  major clinical study;  male;  memory;  Mini Mental State Examination;  priority journal;  risk assessment;  risk factor;  subjective cognitive decline;  very elderly;  clinical trial;  cognitive defect;  dementia;  middle aged;  multicenter study;  psychology;  self concept;  self evaluation, Aged;  Aged, 80 and over;  Cognitive Dysfunction;  Cohort Studies;  Dementia;  Diagnostic Self Evaluation;  Disease Progression;  Female;  Humans;  Incidence;  Male;  Middle Aged;  Risk Factors;  Self Concept
TODO - Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini–Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia. Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts. © 2018 The Authors
ER -