TY - JOUR
TI - The Cretan Aging Cohort: Cohort Description and Burden of Dementia and Mild Cognitive Impairment
AU - Zaganas, I.V.
AU - Simos, P.
AU - Basta, M.
AU - Kapetanaki, S.
AU - Panagiotakis, S.
AU - Koutentaki, I.
AU - Fountoulakis, N.
AU - Bertsias, A.
AU - Duijker, G.
AU - Tziraki, C.
AU - Scarmeas, N.
AU - Plaitakis, A.
AU - Boumpas, D.
AU - Lionis, C.
AU - Vgontzas, A.N.
JO - American Journal of Alzheimer's Disease and other Dementias
PY - 2019
VL - 34
TODO - 1
SP - 23-33
PB - SAGE Publications Inc.
SN - 1533-3175
TODO - 10.1177/1533317518802414
TODO - adult;  aged;  aging;  Article;  clinical trial;  cognition;  cohort analysis;  dementia;  disease burden;  female;  follow up;  human;  Independent Activities of Daily Living scale;  major clinical study;  male;  middle aged;  mild cognitive impairment;  Mini Mental State Examination;  phase 1 clinical trial;  phase 2 clinical trial;  prevalence;  questionnaire;  semi structured interview;  very elderly;  cognitive defect;  cost of illness;  dementia;  dementia assessment;  Greece, Aged;  Aged, 80 and over;  Aging;  Cognitive Dysfunction;  Cohort Studies;  Cost of Illness;  Dementia;  Female;  Greece;  Humans;  Male;  Mental Status and Dementia Tests;  Middle Aged;  Prevalence
TODO - Our aim was to explore the burden of dementia in the Cretan Aging Cohort, comprised of 3140 persons aged ≥60 years (56.8% women, 5.8 ± 3.3 years formal education, 86.2% living in rural areas) who attended selected primary health-care facilities on the island of Crete, Greece. In the first study phase, a formal diagnosis of dementia had been reached in 4.0% of the participants. However, when selected 505 participants underwent thorough neuropsychiatric evaluation in the second phase of this study (344 with Mini-Mental State Examination [MMSE] <24 and 161 with MMSE ≥24), and results were extrapolated to the entire cohort, the prevalence of dementia and mild cognitive impairment was estimated at 10.8% (9.7%-11.9%) and 32.4% (30.8%-34.0%), respectively. Using both the field diagnostic data and the extrapolated data, the highest dementia prevalence (27.2%) was found in the 80- to 84-year-old group, who also showed the lowest educational level, apparently due to lack of schooling during World War II. © The Author(s) 2018.
ER -