TY - JOUR
TI - Modelling reaction time distribution of fast decision tasks in schizophrenia: Evidence for novel candidate endophenotypes
AU - Fish, S.
AU - Toumaian, M.
AU - Pappa, E.
AU - Davies, T.J.
AU - Tanti, R.
AU - Saville, C.W.N.
AU - Theleritis, C.
AU - Economou, M.
AU - Klein, C.
AU - Smyrnis, N.
JO - Psychiatry Research
PY - 2018
VL - 269
TODO - null
SP - 212-220
PB - Elsevier Ireland Ltd
SN - 0165-1781
TODO - 10.1016/j.psychres.2018.08.067
TODO - adult;  Article;  clinical article;  controlled study;  drift diffusion model;  endophenotype;  ex Gaussian model;  female;  first-degree relative;  human;  male;  mathematical model;  mathematical parameters;  priority journal;  reaction time;  schizophrenia;  sibling;  task performance;  working memory;  decision making;  family;  genetics;  neuropsychological test;  pathophysiology;  photostimulation;  physiology;  procedures;  psychology;  reaction time;  schizophrenia;  time factor, Adult;  Decision Making;  Endophenotypes;  Family;  Female;  Humans;  Male;  Neuropsychological Tests;  Photic Stimulation;  Reaction Time;  Schizophrenia;  Schizophrenic Psychology;  Time Factors
TODO - Increased reaction time (RT) and variability of RT in fast decision tasks is observed in patients with schizophrenia and their first degree relatives. This study used modelling of the RT distribution with the aim of identifying novel candidate endophenotypes for schizophrenia. 20 patients with schizophrenia, 15 siblings of patients and 25 healthy controls performed an oddball task of varying working memory load. Increases in mean and standard deviation (SD) of RT were observed for both patients and siblings compared to controls and they were again independent of working memory load. Ex-Gaussian modelling of the RT distribution confirmed that parameters μ σ and τ increased significantly in patients and siblings compared to controls. The Drift Diffusion Model was applied on RT distributions. A decrease in the diffusion drift rate (v) modeling the accumulation of evidence for reaching the decision to choose one stimulus over the other, was observed in patients and siblings compared to controls. The mean time of the non-decisional sensorimotor processes (t0) and it's variance (st0) was also increased in patients and siblings compared to controls. In conclusion modeling of the RT distribution revealed novel potential cognitive endophenotypes in the quest of heritable risk factors for schizophrenia. © 2018
ER -