TY - JOUR
TI - HLA-DRB1*15:01 and Epstein-Barr virus in a multiple sclerosis patient with psoriasis, nasopharyngeal and breast cancers. Lessons for possible hidden links for autoimmunity and cancer
AU - Anagnostouli, M.
AU - Anagnostoulis, G.
AU - Katsavos, S.
AU - Panagiotou, M.
AU - Kararizou, E.
AU - Davaki, P.
JO - Journal of the Neurological Sciences
PY - 2014
VL - 339
TODO - 1-2
SP - 26-31
PB - Elsevier
SN - 0022-510X
TODO - 10.1016/j.jns.2014.02.003
TODO - beta interferon;  HLA DRB1 antigen;  methotrexate;  methylprednisolone;  oligoclonal band;  HLA DRB1 antigen;  HLA-DRB1*15:01 antigen, autoimmunity;  blurred vision;  breast cancer;  case report;  cognitive defect;  depression;  disease course;  Epstein Barr virus infection;  female;  follow up;  hospital admission;  human;  immunogenetics;  immunopathogenesis;  limb dysesthesia;  lumbar puncture;  multiple sclerosis;  nasopharynx cancer;  neurologic examination;  nuclear magnetic resonance imaging;  optic neuritis;  priority journal;  psoriasis;  review;  serology;  unsteady gait;  uterus myoma;  autoimmunity;  blood;  Breast Neoplasms;  Epstein Barr virus;  immunology;  metabolism;  middle aged;  multiple sclerosis;  Nasopharyngeal Neoplasms;  psoriasis, Autoimmunity;  Breast Neoplasms;  Female;  Follow-Up Studies;  Herpesvirus 4, Human;  HLA-DRB1 Chains;  Humans;  Middle Aged;  Multiple Sclerosis;  Nasopharyngeal Neoplasms;  Psoriasis
TODO - Background Multiple sclerosis (MS) patients have a low general cancer risk and cases of neoplastic comorbidity are attributed by many researchers in chance, or therapeutical side-effects. Human leucocyte antigen (HLA) class II allele DRB1*15:01 is considered the main genetic factor independently associated with increased susceptibility for MS in Caucasians. Epstein-Barr virus (EBV) has also been proven to be a core triggering factor in MS initiation and progress, mainly in HLA-DRB1*15:01 positive MS patients. Case report We present an exceptional case of a Greek-origin woman, carrying a distinct immunogenetic profile (HLA-A*26:01-Cw*06:02-DRB1*15:01), which gradually developed psoriasis, nasopharyngeal carcinoma (NPC), MS, breast cancer, uterine leiomyoma and other neoplasms. Discussion EBV plays a fundamental role in the pathogenesis of both autoimmunity (i.e. MS) and cancer (i.e. NPC). Our patient's immunogenetic profile included HLA alleles which are associated with psoriasis (Cw*06:02), NPC (A*26:01), MS (DRB1*15:01) and increased risk of MS, in patients carrying EBV (DRB1*15:01). We made a targeted review of the literature finding data supporting an EBV-HLA interaction mechanism behind our patient's unique combination of disorders, suggesting that beyond the standard role of each factor, their combination could act as the hidden link, in initiation or/and comorbidity of autoimmunity and cancer. © 2014 Elsevier B.V.
ER -