TY - JOUR
TI - Evidence for respiratory viruses interactions in asymptomatic preschool-aged children
AU - Douros, K.
AU - Kotzia, D.
AU - Kottaridi, C.
AU - Giotas, A.
AU - Boutopoulou, B.
AU - Bozas, E.
AU - Matziou, V.
AU - Priftis, K.
AU - Papaevangelou, V.
JO - Allergologia et Immunopathologia
PY - 2019
VL - 47
TODO - 3
SP - 260-264
PB - Elsevier España (Elsevier Doyma)
SN - 0301-0546
TODO - 10.1016/j.aller.2018.07.005
TODO - Adenoviridae;  article;  child;  DNA microarray;  DNA RNA hybridization;  female;  human;  Human respiratory syncytial virus;  Influenza virus;  major clinical study;  male;  nonhuman;  prospective study;  reverse transcription polymerase chain reaction;  Rhinovirus;  throat culture;  upper respiratory tract;  Adenoviridae;  adenovirus infection;  asymptomatic disease;  common cold;  Greece;  influenza;  Orthomyxoviridae;  physiology;  Pneumovirus;  preschool child;  prognosis;  respiratory syncytial virus infection;  respiratory tract infection, Adenoviridae;  Adenoviridae Infections;  Asymptomatic Diseases;  Child, Preschool;  Common Cold;  Female;  Greece;  Humans;  Influenza, Human;  Male;  Orthomyxoviridae;  Prognosis;  Prospective Studies;  Respiratory Syncytial Virus Infections;  Respiratory Syncytial Viruses;  Respiratory Tract Infections;  Rhinovirus
TODO - Aim: To prospectively evaluate interferences between viruses of the upper respiratory tract in asymptomatic preschool children. Methods: Nasal-pharyngeal swabs from 233 preschool aged children were prospectively collected over four consecutive time periods, during one school year. The samples were tested using a RT-PCR DNA/RNA microarray system for nine respiratory viruses. Results: Respiratory syncytial virus (RSV) was a predictor of the presence of influenza virus (INFL) (OR: 9.12, CI: 1.52–54.75, p = 0.016), and similarly, INFL predicted the presence of RSV (OR: 4.01, CI: 1.14–14.16, p = 0.030). Also, rhinovirus (RV) was a predictor of adenovirus (ADV) presence (OR: 3.66, CI: 1.10–12.14, p = 0.034), and similarly, ADV predicted the presence of RV (OR: 4.05, CI: 1.02–16.05, p = 0.046). No other significant associations between viruses were observed. Conclusion: Our results indicate that respiratory viruses found in carrier stage in asymptomatic children may interact with other viruses and even facilitate their settling in the upper respiratory tract. The pathophysiological role of these interactions is not yet clear. © 2018 SEICAP
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