TY - JOUR
TI - Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey
AU - Datema, M.R.
AU - Zuidmeer-Jongejan, L.
AU - Asero, R.
AU - Barreales, L.
AU - Belohlavkova, S.
AU - De Blay, F.
AU - Bures, P.
AU - Clausen, M.
AU - Dubakiene, R.
AU - Gislason, D.
AU - Jedrzejczak-Czechowicz, M.
AU - Kowalski, M.L.
AU - Knulst, A.C.
AU - Kralimarkova, T.
AU - Le, T.-M.
AU - Lovegrove, A.
AU - Marsh, J.
AU - Papadopoulos, N.G.
AU - Popov, T.
AU - Del Prado, N.
AU - Purohit, A.
AU - Reese, G.
AU - Reig, I.
AU - Seneviratne, S.L.
AU - Sinaniotis, A.
AU - Versteeg, S.A.
AU - Vieths, S.
AU - Zwinderman, A.H.
AU - Mills, C.
AU - Lidholm, J.
AU - Hoffmann-Sommergruber, K.
AU - Fernández-Rivas, M.
AU - Ballmer-Weber, B.
AU - Van Ree, R.
JO - Allergy: European Journal of Allergy and Clinical Immunology
PY - 2015
VL - 136
TODO - 2
SP - 382-391
PB - Mosby Year Book Inc
SN - null
TODO - 10.1016/j.jaci.2014.12.1949
TODO - carbohydrate;  food allergen;  immunoglobulin E antibody;  latex;  oleosin;  pollen antigen;  seed storage protein;  unclassified drug;  allergen;  carrier protein;  Cor a 8 allergen, Corylus avellana;  immunoglobulin E;  lipid transfer protein;  oleosin, Corylus avellana;  plant antigen, adolescent;  allergy rapid test;  anaphylaxis;  Article;  birch;  child;  clinical evaluation;  cross reaction;  Europe;  female;  hazelnut allergy;  human;  major clinical study;  male;  nut allergy;  outpatient department;  prick test;  priority journal;  provocation test;  sensitization;  adult;  blood;  chemistry;  double blind procedure;  hazelnut;  immunology;  middle aged;  molecular epidemiology;  Nut Hypersensitivity;  pathophysiology;  pollen;  skin test;  statistics and numerical data, Adolescent;  Adult;  Allergens;  Ambulatory Care Facilities;  Antigens, Plant;  Betula;  Carrier Proteins;  Corylus;  Cross Reactions;  Double-Blind Method;  Europe;  Female;  Humans;  Immunoglobulin E;  Male;  Middle Aged;  Molecular Epidemiology;  Nut Hypersensitivity;  Pollen;  Skin Tests
TODO - Background Hazelnut allergy is birch pollen-driven in Northern/Western Europe and lipid transfer protein-driven in Spain and Italy. Little is known about other regions and other allergens. Objective Establishing a molecular map of hazelnut allergy across Europe. Methods In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization to 24 foods, 12 respiratory allergen sources, and latex was tested by using skin prick test and ImmunoCAP. A subset (124 of 731) underwent a double-blind placebo-controlled food challenge to hazelnut. Sera of 423 of 731 subjects were analyzed for IgE against 7 hazelnut allergens and cross-reactive carbohydrate determinants by ImmunoCAP. Results Hazelnut allergy was confirmed in 70% of those undergoing double-blind placebo-controlled food challenges. Birch pollen-driven hazelnut sensitization (Cor a 1) dominated in most cities, except in Reykjavik, Sofia, Athens, and Madrid, where reporting of hazelnut allergy was less frequent anyhow. In Athens, IgE against Cor a 8 dominated and strongly correlated with IgE against walnut, peach, and apple and against Chenopodium, plane tree, and mugwort pollen. Sensitization to seed storage proteins was observed in less than 10%, mainly in children, and correlated with IgE to nuts, seeds, and legumes. IgE to Cor a 12, observed in all cities (10% to 25%), correlated with IgE to nuts, seeds, and pollen. Conclusions In adulthood, the importance of hazelnut sensitization to storage proteins, oleosin (Cor a 12), and Cor a 8 is diluted by the increased role of birch pollen cross-reactivity with Cor a 1. Cor a 8 sensitization in the Mediterranean is probably driven by diet in combination with pollen exposure. Hazelnut oleosin sensitization is prevalent across Europe; however, the clinical relevance remains to be established. © 2015 American Academy of Allergy, Asthma & Immunology.
ER -