TY - JOUR
TI - Soluble form of ICAM-1, VCAM-1, E-and L-selectin in human milk
AU - Xyni, K.
AU - Rizos, D.
AU - Giannaki, G.
AU - Sarandakou, A.
AU - Phocas, I.
AU - Creatsas, G.
JO - Mediators of Inflammation
PY - 2000
VL - 9
TODO - 3-4
SP - 133-140
PB - Carfax Publishing Company
SN - 0962-9351, 1466-1861
TODO - 10.1080/09629350020003858
TODO - cell adhesion molecule;  endothelial leukocyte adhesion molecule 1;  intercellular adhesion molecule 1;  L selectin;  vascular cell adhesion molecule 1, article;  blood sampling;  breast feeding;  breast milk;  cell differentiation;  cell maturation;  colostrum;  enzyme linked immunosorbent assay;  human;  human cell;  immune system;  immunomodulation;  immunoregulation;  lactation;  maternal serum;  priority journal;  vein puncture
TODO - In breast milk and paired serum from 70 lactating women and 40 of their term, infection-free neonates, on the 2nd and 5th day postpartum slCAM-1, sVCAM-1, sE- and sL-selectin were measured by ELISA and compared with those in 26 healthy adults (controls). Seven infant formulas and fresh milk from five cows were also analyzed. Human colostrum values of slCAM-1, sVCAM-1 (similar to those in maternal and control serum), sE-selectin and sL-selectin (~10 and ~100 times lower than in maternal and control serum) were significantly higher than those in milk, while they varied widely. None of the adhesion molecules was detected in fresh cow's milk or infant formulas. Exclusively breast-fed infants showed significantly higher values of slCAM-1 and sL-selectin on the 2nd day of life than those supplemented also with formula. Only slCAM-1 values correlated positively between colostrum and time-matched maternal serum. These findings show in human milk important amounts of slCAM-1 and sVCAM-1 but minimal amounts of sE- and sL-selectin, which could affect the immune system of the neonate.
ER -