TY - JOUR
TI - The Effect of Perioperative Ischemia and Reperfusion on Multiorgan Dysfunction following Abdominal Aortic Aneurysm Repair
AU - Katseni, K.
AU - Chalkias, A.
AU - Kotsis, T.
AU - Dafnios, N.
AU - Arapoglou, V.
AU - Kaparos, G.
AU - Logothetis, E.
AU - Iacovidou, N.
AU - Karvouni, E.
AU - Katsenis, K.
JO - BioMed Research International
PY - 2015
VL - 2015
TODO - null
SP - null
PB - Hindawi Publishing Corporation
SN - 2314-6133, 2314-6141
TODO - 10.1155/2015/598980
TODO - animal;  Aortic Aneurysm, Abdominal;  human;  multiple organ failure;  pathology;  pathophysiology;  postoperative complication;  reperfusion injury, Animals;  Aortic Aneurysm, Abdominal;  Humans;  Multiple Organ Failure;  Postoperative Complications;  Reperfusion Injury
TODO - Abdominal aortic aneurysms (AAAs) are relatively common and are potentially life-Threatening medical problems. The aim of this review is to provide an overview of the effect of I/R injury on multiorgan failure following AAA repair. The PubMed, CINAHL, EMBASE, Medline, Cochrane Review, and Scopus databases were comprehensively searched for articles concerning the pathophysiology of I/R and its systemic effects. Cross-referencing was performed using the bibliographies from the articles obtained. Articles retrieved were restricted to those published in English. One of the most prominent characteristics of AAA open repair is the double physiological phenomenon of ischemia-reperfusion (I/R) that happens either at the time of clamping or following the aortic clamp removal. Ischemia-reperfusion injury causes significant pathophysiological disturbances to distant organs, increasing the possibility for postoperative multiorgan failure. Although tissue injury is mediated by diverse mechanisms, microvascular dysfunction seems to be the final outcome of I/R. © 2015 Konstantina Katseni et al.
ER -