TY - JOUR
TI - Chemokine CXCL-1: Activity in the vitreous during proliferative vitreoretinopathy
AU - Symeonidis, C.
AU - Androudi, S.
AU - Georgalas, I.
AU - Tzamalis, A.
AU - Chalvatzis, N.
AU - Rotsos, T.
AU - Souliou, E.
AU - Diza, E.
AU - Dimitrakos, S.A.
JO - Clinical and Experimental Immunology
PY - 2015
VL - 181
TODO - 2
SP - 338-342
PB - Wiley-Blackwell Publishing Ltd
SN - null
TODO - 10.1111/cei.12627
TODO - CXCL1 chemokine;  biological marker;  CXCL1 chemokine;  CXCL1 protein, human, adult;  aged;  Article;  clinical article;  controlled study;  disease duration;  enzyme linked immunosorbent assay;  female;  human;  human tissue;  male;  organ donor;  priority journal;  retina detachment;  very elderly;  vitreoretinopathy;  vitreous biopsy;  vitreous body;  case control study;  chemistry;  complication;  Eye Diseases, Hereditary;  gene expression;  genetics;  immunology;  metabolism;  middle aged;  pathology;  retina;  Retinal Detachment;  severity of illness index;  subretinal fluid;  Vitreoretinopathy, Proliferative, Adult;  Aged;  Aged, 80 and over;  Biomarkers;  Case-Control Studies;  Chemokine CXCL1;  Eye Diseases, Hereditary;  Female;  Gene Expression;  Humans;  Male;  Middle Aged;  Retina;  Retinal Detachment;  Severity of Illness Index;  Subretinal Fluid;  Vitreoretinopathy, Proliferative;  Vitreous Body
TODO - The aim of this study was to investigate CXCL-1 chemokine levels in the vitreous during rhegmatogenous retinal detachment (RRD) with and without proliferative vitreoretinopathy (PVR) and identify possible correlations with clinical parameters (extent and duration or RRD and PVR grade). Vitreous samples from patients with primary RRD with or without PVR were collected and assayed using a double antibody enzyme-linked immunosorbent assay (ELISA). Eleven vitreous samples from organ donors were employed as a control group. CXCL-1 levels were measured in 35 vitreous samples from 35 RRD patients. Mean CXCL-1 levels (64·82±6·47 pg/ml) were significantly higher (P = 0·048) compared to controls. There was a significant positive correlation between CXCL-1 levels and the extent of the detachment (r=0·794, P = 0·006). Peak CXCL-1 levels coincided with 3+ quadrant RRD, an interim of 29-60 days' duration and PVR grade B. Increased CXCL-1 levels may be indicative of mild inflammation in the detached retina and the adjacent vitreous. The results of the present study may provide novel insight into the complex interactions taking place during the early and late stages of RRD complicated by PVR. © 2015 British Society for Immunology.
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