TY - JOUR
TI - Transmission of trained immunity and heterologous resistance to infections across generations
AU - Katzmarski, N.
AU - Domínguez-Andrés, J.
AU - Cirovic, B.
AU - Renieris, G.
AU - Ciarlo, E.
AU - Le Roy, D.
AU - Lepikhov, K.
AU - Kattler, K.
AU - Gasparoni, G.
AU - Händler, K.
AU - Theis, H.
AU - Beyer, M.
AU - van der Meer, J.W.M.
AU - Joosten, L.A.B.
AU - Walter, J.
AU - Schultze, J.L.
AU - Roger, T.
AU - Giamarellos-Bourboulis, E.J.
AU - Schlitzer, A.
AU - Netea, M.G.
JO - Nature Immunology
PY - 2021
VL - 22
TODO - 11
SP - 1382-1390
PB - Institute of Geographic Sciences and Natural Resources Research
SN - 1529-2908, 1529-2916
TODO - 10.1038/s41590-021-01052-7
TODO - DNA;  meloxicam, animal cell;  animal experiment;  animal model;  animal tissue;  Article;  candidiasis;  controlled study;  DNA methylation;  effector cell;  epigenetics;  Escherichia coli infection;  female;  gene locus;  hematopoietic stem cell;  infection resistance;  innate immunity;  listeriosis;  male;  mouse;  myeloid progenitor cell;  nonhuman;  progeny;  sperm;  stem cell;  trained immunity;  transcription regulation;  animal;  bone marrow cell;  Candida albicans;  candidiasis;  cell culture;  disease model;  Escherichia coli;  Escherichia coli infection;  genetic epigenesis;  genetic transcription;  genetics;  heredity;  host pathogen interaction;  immunology;  innate immunity;  Listeria monocytogenes;  listeriosis;  metabolism;  microbiology;  pathogenicity;  spermatozoon;  transgenic mouse, Animals;  Candida albicans;  Candidiasis;  Cells, Cultured;  Disease Models, Animal;  DNA Methylation;  Epigenesis, Genetic;  Escherichia coli;  Escherichia coli Infections;  Heredity;  Host-Pathogen Interactions;  Immunity, Innate;  Listeria monocytogenes;  Listeriosis;  Male;  Mice, Transgenic;  Myeloid Cells;  Spermatozoa;  Transcription, Genetic
TODO - Intergenerational inheritance of immune traits linked to epigenetic modifications has been demonstrated in plants and invertebrates. Here we provide evidence for transmission of trained immunity across generations to murine progeny that survived a sublethal systemic infection with Candida albicans or a zymosan challenge. The progeny of trained mice exhibited cellular, developmental, transcriptional and epigenetic changes associated with the bone marrow-resident myeloid effector and progenitor cell compartment. Moreover, the progeny of trained mice showed enhanced responsiveness to endotoxin challenge, alongside improved protection against systemic heterologous Escherichia coli and Listeria monocytogenes infections. Sperm DNA of parental male mice intravenously infected with the fungus C. albicans showed DNA methylation differences linked to immune gene loci. These results provide evidence for inheritance of trained immunity in mammals, enhancing protection against infections. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
ER -